Two new simple, accurate and economic spectrophotometric methods in UV/VIS region have been developed for the determination of Ketoconazole and Salicylic Acid in bulk and lotion formulation. Due to mutual interference, quantitation was carried out by the proposed methods such as simultaneous equation Method and absorbance ratio Method. The wavelengths selected for simultaneous equation method were 261.00 nm and 255.00 nm i.e. the respective λ max of both the drugs. In absorbance ratio method, two wavelengths 261.00 nm, λ max of Ketoconazole and 295.00 nm, the iso-absorptive point were selected. Two methods follow Beer's linearity in the range of 10-35 µg/ml for Ketoconazole and 10-35 µg/ml for salicylic acid with correlation coefficient r 2 of 0.999 for Ketoconazole and Salicylic acid respectively. According to ICH guidelines the parameters linearity, precision, accuracy, limit of detection, and limit of quantification, robustness, ruggedness were studied, the results of analysis were validated statistically and by recovery studies.Recovery studies for Ketoconazole and Salicylic acid were performed and the percentage recovery for both the drugs was obtained in the range of 98.36-102.84% (Method A) and 97.48-100.7% (Method B) confirming the accuracy of the proposed method. The proposed methods were simple, cost effective and were successfully applied to the determination of these drugs in quality control of combined pharmaceutical dosage.
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