The present manuscript describes a simple, sensitive, accurate, precise and economical visible spectrophotometric method for the estimation of azithromycin from tablet formulation. The method is based on the reduction of potassium permanganate in alkaline medium with azithromycin. The measurement of decrease in absorbance of potassium permanganate at 547 nm was done, as it decolourises upon reduction by azithromycin. The method was used to determine between 2 and 20 μg/ml of azithromycin in the final measured solution. There is no interference from the ingredients commonly found in azithromycin tablets with this method. The results for the determination of azithromycin in tablets were in good agreement with the labelled quantities and related analytical parameters are calculated.
A simple, accurate and sensitive spectrophotometric method has been developed for the analysis of four cephalosporins, ceftriaxone (CEFT), cefatoxime (CEFX), ceftazidime (CEZD) and cefepime (CEPM) in bulk and in pharmaceutical formulations. The method is based on the diazotization of cephalosporins in acidic medium, followed by coupling with 3-amino phenol (AP), to give orange red colored product having a λ max of 500 nm. The calibration graphs are rectilinear in the concentration ranges 20 -160 μg mL -1 for CEFT, 20 -140 μg mL -1 for CEFX & CEPM and 24 -168 μg mL -1 for CEZD respectively in the final measured solution. All the optimum conditions are established and other analytical parameters are evaluated. Commonly associated excipients did not interfere with the determinations. Statistical analysis of results indicates that the method is precise and accurate.
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