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Summary. The venom of the Gaboon viper (Bitis gabonica) has been shown to possess both coagulant and anticoagulant activities in vitro. These findings confirm in part previous results, the latter effect probably being achieved by proteolytic breakdown of fibrinogen.A partially purified coagulant has been recovered by ion‐exchange chromatography and gel filtration. Initial results indicate that this material may be similar in some respects to ancrod and reptilase. Anaesthetized rabbits were totally defibrinated without any apparent short‐term deleterious effects.

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