SynopsisThe effects of concentrated aqueous solutions of a neutral salt', lithium bromide, on randomly coiled sodium poly-L-glutamate have been followed using high resolution infrared and nuclear magnetic resonance spect.roscopy. The results suggest that two processes are taking place. First, at low concentrations 0 4 M LiBr, a simple electrolyte effect occurs in which some water is removed from the polymer by an electrostriction effect. Second, a more intense interaction (>4M LiBr), apparently cooperative, occurs in which the competition for the available water in the system forces the electrolyte to form an association with the peptide group either a fully or partially hydrated species. I t is proposed that the anion is associated with the nitrogen atom of the peptide group and the cation is situated within the vicinity of the carbonyl oxygen.
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