The nonclassic clinical presentation of celiac disease (CD) becomes increasingly common in physician's daily practice, which requires an awareness of its many clinical faces with atypical, silent, and latent forms. Besides the common genetic background (HLA DQ2/DQ8) of the disease, other non-HLA genes are now notably reported with a probable association to atypical forms. The availability of high-sensitive and specific serologic tests such as antitissue transglutuminase, antiendomysium, and more recent antideamidated, gliadin peptide antibodies permits to efficiently uncover a large portion of the submerged CD iceberg, including individuals having conditions associated with a high risk of developing CD (type 1 diabetes, autoimmune diseases, Down syndrome, family history of CD, etc.), biologic abnormalities (iron deficiency anemia, abnormal transaminase levels, etc.), and extraintestinal symptoms (short stature, neuropsychiatric disorders, alopecia, dental enamel hypoplasia, recurrent aphtous stomatitis, etc.). Despite the therapeutic alternatives currently in developing, the strict adherence to a GFD remains the only effective and safe therapy for CD.

No abstract

No abstract

We describe a rare case of the spinal cord compression by a primary Ewing sarcoma of the thoracolumbar spine. A 16-year-old boy was admitted with back pain for 2 month and inability to walk for 15 days. At the presentation, he had paraparesis and bilateral hypoesthesia below the T12 level, without sphincter dysfunction. Thoracolumbar spine magnetic resonance imaging showed an involved vertebral body mass of the L1 extending in the epidural space with an extension into the prevertebral area. The mass was totally removed by the anterolateral approach. Histopathological examination revealed Ewing sarcoma. Although his infrequency, such a primary Ewing sarcoma of the vertebral column should be suspected for lesion causing a spinal cord compression particularly in the children and adolescent that the treatment protocol included a three main modalities: surgery, radiotherapy and chemotherapy.