Objective: The present work was carried out to design microemulsion gel system for transdermal delivery of the drug to minimize the side effects and to reduce the frequency of administration and for prolonging the duration of action. Methods: Tramadol, an opioid analgesic drug, was mixed with various selected polymers such as sodium alginate (SA), acacia, hydroxypropyl methylcellulose (HPMC), and Eudragit in geometric mixing ratios. The drug, polymer, and other excipients were mixed thoroughly by trituration method and different formulations (F1-F8) were prepared the same quantity of all the ingredients excepting the polymers. Results: The different formulations prepared, studied, and showed that the formulation using SA as polymeric carrier had a better effect on the evaluated parameters. The drug-SA formulation exhibited better drug-polymer compatibility, optimal viscosity (2750 cps), zeta potential (−26.1 Mv), and particle size distribution (262.8 d.nm) values. The in vitro release studies also indicated that the drug-SA formulation was of desirable release pattern, thus indicating that SA to be a better choice in formulating a transdermal delivery gel system. Conclusion: Evaluated microemulsion gel formulation F2 of tramadol with polymeric carriers SA was much stable than other carriers used. Thus, it could be concluded that the gel formulation with SA can be taken as an ideal formulation.
Background:Dyslipidemia, a major risk factor of coronary heart disease, is the leading single cause of death in the world. Currently available hypolipidemic agents have been associated with a large number of side effects. The radical Ayurveda Samshodhana Chikitsa as a treatment protocol can provide better effect. Therefore, the present study was designed to evaluate the effect of Virechana Karma and Lekhana Basti in dyslipidemia.Objectives:To evaluate the effect of Virechana Karma and Lekhana Basti in the management of dyslipidemia (Medoroga).Materials and Methods:Ninety patients of either sex in the age group of 20–60 years, fulfilling the study criteria were included in the study. The patients were randomly divided into three groups (thirty patients each). Virechana Karma was administered to patients in group A, Lekhana Basti was administered in group B and tablet Atorvastatin in group C. The effect of treatment was assessed by analyzing the complete lipid profile after completion of treatment and after the follow up in comparison to base line score.Results:All the three groups showed statistically highly significant result in the lipid profile after the treatment and after the follow up.Conclusion:Virechana Karma is effective in reducing triglycerides level, where as Lekhana Basti is effective in reducing the cholesterol level in particular.
The objective of the study was to investigate the effect of telmisartan and rutin in High Fructose Diet plus alcohol induced metabolic syndrome in rats. Our study demonstrated the beneficial effects of telmisartan and rutin on both abnormal metabolic characters and vascular dysfunction in insulin resistant rats. Initially we have validated the pre diabetic metabolic syndrome rat model by feeding high fructose diet to the male Sprague Dawley rats. Development of metabolic syndrome and glucose intolerance was assessed by performing the plasma biochemical analysis such as plasma glucose, triglyceride, insulin and total cholesterol levels. Glucose intolerance was assessed by performing an intra peritoneal glucose tolerance test and Histopathological studies of Liver were conducted. In the present study, we examined the effect telmisartan and rutin and the relationship between the plasma adiponectin concentration and adiposity, body fat distribution, lipid profile, renal profile, liver enzymes, Cardio vascular parameters, histopathology of Liver, in high fructose diet fed Sprague-dawley rats. It was concluded that telmisartan and rutin are effective in treating metabolic dysfunction and alcohol induced liver toxicity Further studies are needed to explore the underlying mechanisms.
Ulcerative colitis (UC) is a form of inflammatory bowel disease (IBD) that causes inflammation and ulcers in the colon. The disease is a type of colitis, which is a group of diseases that cause inflammation of the colon, the largest section of the large intestine, either in segments or completely. The main symptom of this active disease is diarrhea mixed with blood. In Ayurveda, it can be compared with a disease Pravahika characterized by Atidrava Mala Pravrutti with Rakta. A 30 year old female patient reported to the out patient Department of Panchakarma, NIA, Jaipur, with the complaints of frequent loose, watery, frothy, and foul-smelling stool stained with mucous and blood. Other associated complaints were reduced appetite, distension and pain in the abdomen, weakness, heat intolerance, reduced sleep, and headache. The patient was diagnosed as IBD consistent with UC. A combination of Nagarmotha (Cyperus rotundus L.) 2 g, Indrayava (Holarrhena antidysenterica (L.) Wall.) 1 g, Nagakeshara (Mesua ferrea L.) 1 g, Madhuyashti (Glycyrrhiza glabra L.) 1 g, and Amalaki (Emblica officinalis Gaertn.) 1 g powders three times a day, along with Dadimashtaka Choorna 3 g with Shankha Bhasma 500mg three times a day, Mustarista 2 tsp three times a day after food, and Dhanyapanchaka Kvatha 20ml two times a day before food was administered for 2months. After the 2-month treatment, a significant response in various symptoms such as frequent defecation, abdomen distension, headache, heat intolerance, and reduced sleep was found.
Background: Kasisadi churna is a yoga (formulation) mentioned for treatment of kaphaja yoni vyapath (vulvo vaginal candidiasis) which is applied as lepa along with honey. But the administration of the drug through vaginal route in this form is highly discomforting. Modification of a dosage form is essential for the enhancement of efficacy, acceptability of the product and shelf life. Materials and Methods: Varti is prepared from the drugs of kasisadi churna in three methods, bhavana method (KV1), gudapaka method (KV2) and modified method (KV3) with the addition of cocoa butter as base. The prepared samples were tested for analytical parameters. Result and Discussion: Kasisadi churna can be easily modified into varti form. Preparation of KV2 was easy, gives more yield in less time and better in organoleptic features and disintegration time compared to KV1 and KV3. Conclusion: The results of the pharmaceutical and analytical study can be considered as the preliminary standards for the preparation of Kasisadi Varti.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.