Effect of Telmisartan and Rutin in Alcohol Plus High Fructose Diet Induced Metabolic Dysfunction in Rats

Abstract

The objective of the study was to investigate the effect of telmisartan and rutin in High Fructose Diet plus alcohol induced metabolic syndrome in rats. Our study demonstrated the beneficial effects of telmisartan and rutin on both abnormal metabolic characters and vascular dysfunction in insulin resistant rats. Initially we have validated the pre diabetic metabolic syndrome rat model by feeding high fructose diet to the male Sprague Dawley rats. Development of metabolic syndrome and glucose intolerance was assessed by performing the plasma biochemical analysis such as plasma glucose, triglyceride, insulin and total cholesterol levels. Glucose intolerance was assessed by performing an intra peritoneal glucose tolerance test and Histopathological studies of Liver were conducted. In the present study, we examined the effect telmisartan and rutin and the relationship between the plasma adiponectin concentration and adiposity, body fat distribution, lipid profile, renal profile, liver enzymes, Cardio vascular parameters, histopathology of Liver, in high fructose diet fed Sprague-dawley rats. It was concluded that telmisartan and rutin are effective in treating metabolic dysfunction and alcohol induced liver toxicity Further studies are needed to explore the underlying mechanisms.

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“…[12,35] Inflammation is either due to elevated levels of proinflammatory cytokines or CRP and along with decreased adiponectin levels are responsible for IR. [8,13] CRP is an acute phase protein, released under the stimulation of TNF-α and IL-6. Often chronic low-grade inflammation decreases IS and play a pathological role in the development of IR and diabetes.…”

“…The unwanted effects of PGZ include weight gain, hip fractures, heart failure, bladder cancer, and nonrecommendable for obese and CV diseases (CVD) patients. [12,13] Till date, there is no safer insulin sensitizers available and often individuals with IR use either medicinal plants or alternative therapies and their efficacy is still undetermined. [14] Since ages, the importance of several medicinal plants has been mentioned in the treatment of diabetes.…”