This paper presents a self-powered interface circuit to extract energy from ambient vibrations for powering up microelectronic devices. The circuit interfaces a piezoelectric energy harvesting micro electro-mechanical systems (MEMS) device to scavenge acoustic energy. Synchronous electric charge extraction (SECE) technique is deployed through the implementation of a novel multistage energy extraction (MSEE) circuit in 180 nm HV CMOS technology to harvest and store energy. The circuit is optimized to operate with minimum power losses when input power is limited, and adapts well to operating conditions with higher input power. The highly accurate peak detector was validated for a wide piezoelectric frequency range from 20 Hz to 4 kHz. A charging efficiency of about 84% has been achieved for 4.75 V open-circuit piezoelectric voltage excited at 390 Hz input vibration under nominal input power range of 30-80 µW. Power optimizations enable the circuit to maintain a conversion efficiency of 47% at input power level as low as 3.12 µW. MSEE provides up to 15% efficiency improvement compared to traditional SECE, and maintains power efficiency as high as possible for a wide input power range. Index Terms-Interface circuit (IC), multistage energy extraction (MSEE), piezoelectric energy harvester (PEH), power efficiency, self powered, vibration.
Dielectrophoresis (DEP), a technique used to separate particles based on different sizes and/or dielectric properties under nonuniform electric field, is a promising method to be applied in label-free, rapid, and effective cell manipulation and separation. In this study, a microelectromechanical systems-based, isolated 3D-electrode DEP device has been designed and implemented for the label-free detection of multidrug resistance in K562 leukemia cells, based on the differences in their cytoplasmic conductivities. Cells were hydrodynamically focused to the 3D-electrode arrays, placed on the side walls of the microchannel, through V-shaped parylene-C obstacles. 3D-electrodes extruded along the z-direction provide uniformly distributed DEP force through channel depth. Cell suspension containing resistant and sensitive cancer cells with 1:100 ratio was continuously flown through the channel at a rate of 10 μL/min. Detection was realized at 48.64 MHz, the cross-over frequency of sensitive K562 cells, at which sensitive cells flow with the fluid, while the resistant ones are trapped by positive DEP force. Device can be operated at considerably low voltages (<9 Vpp ). This is achieved by means of a very thin (0.5 μm) parylene coating on electrodes, providing the advantages offered by the isolation of electrodes from the sample, while the working voltage can still be kept low. Results prove that the presented DEP device can provide an efficient platform for the detection of multidrug resistance in leukemia, in a label-free manner.
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