The complexes containing diethylamino substituents exhibit promising cytotoxicity against the estrogen receptor (ER) negative MDA-MB-231 breast cancer cell line.
Superparamagnetic iron oxide nanoparticles were synthesized by simple co-precipitation method and modified with different coating agents such as ascorbic acid, hexanoic acid, salicylic acid, L-arginine and L-cysteine. The synthesized nanoparticles were characterized by various techniques such as FT IR, XRD, VSM, SEM, TEM and thermal analysis. Both bare and coated magnetites were of cubic spinel structure and spherical in shape. All the magnetite nanoparticles showed superparamagnetic behaviour with high saturated magnetization. In vitro cytotoxicity test of bare and coated nanoparticles was performed using adenocarcinoma cells, A549. Cell viability of bare and L-arginine coated magnetite nanoparticles showed IC 50 value of 31.2 µg/mL proving the compatibility of nanocarriers when compared to others. Hence, L-arginine coated nanoparticles were used for loading the drug paclitaxel and the observed IC 50 value (7.8 µg/mL) shows its potent anti-proliferative effect against A549 lung cancer cell lines. Thus, it can be speculated that the drug paclitaxel loaded L-arginine coated nanoparticles could be used as an effective drug carrier for the destruction of cancer cells.
The biological activity of metal(ii) complexes of tetrazolo[1,5-a]pyrimidine ligands show that the copper(ii) complexes may act as promising anticancer agents.
β-Diketiminate ligands with varying degrees of steric bulkiness and having −CN and −NO 2 groups on N-aryl substituents were synthesized. The catalytic activity of some of their [LZnEt] and [LZnOMe] 2 complexes (L = β-diketiminato) toward the copolymerization of carbon dioxide and cyclohexene oxide was explored. All the catalysts were found to be highly active and showed very good turnover frequency, and the polycarbonates produced have a very high percentage of carbonate linkages. The complex [L iPr,Me-CN ZnEt] showed very high activity and selectivity on par with its zinc methoxide analogue. The polymers produced by [LZnEt] complexes displayed a bimodal molecular weight distribution.
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