SummarySwarming in Pseudomonas aeruginosa is a coordinated movement of bacteria over semisolid surfaces (0.5%–0.7% agar). On soft agar, P. aeruginosa exhibits a dendritic swarm pattern, with multiple levels of branching. However, the swarm patterns typically vary depending upon the experimental design. In the present study, we show that the pattern characteristics of P. aeruginosa swarm are highly environment dependent. We define several quantifiable, macroscale features of the swarm to study the plasticity of the swarm, observed across different nutrient formulations. Furthermore, through a targeted screen of 113 two-component system (TCS) loci of the P. aeruginosa strain PA14, we show that forty-four TCS genes regulate swarming in PA14 in a contextual fashion. However, only four TCS genes—fleR, fleS, gacS, and PA14_59770—were found essential for swarming. Notably, many swarming-defective TCS mutants were found highly efficient in biofilm formation, indicating opposing roles for many TCS loci.
Fluorescent silicon nanoparticles (SiNPs) might be one of the excellent candidates for use as optical markers in optical sensing, biological profiling, and diagnostic applications.
All over the world infectious diseases are responsible for high morbidity and mortality. Incidences of emerging infectious diseases in human beings have increased within the recent past few years. From times immemorial, herbal medicines have been used for healing purposes. On the other hand, synthetic drugs are dangerous and have numerous side effects leading to loss of human health. At the same time a continuous consumption of synthetic drugs can lead to serious issues like development of drug resistance. As herbal medicines cause very few side effects so these are regaining much popularity. This article reviews role of herbal drugs in treatment of some parasitic diseases like Filariasis, Leishmaniasis, Amoebiasis, Teaniasis, Malaria and Ascariasis.
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