The delay in the diagnosis of oral cancer has been variously reported as being contributed by the clinicians, patients or both. The purpose of this study was to evaluate the referral pattern of 65 patients eventually diagnosed as having oral squamous cell carcinoma. The results showed that 50% of the patients delayed seeking professional help for more than 3 months after being aware of the lesion. The majority of the patients consulted medical practitioners as the first source of help. The mean clinicians' and patients' delay were 10.3 weeks and 28.9 weeks respectively. Dental practitioners showed a tendency to refer more advanced lesions compared to the medical practitioners. The findings raise the concern that lack of patients' awareness, misdiagnosis by clinicians and late detection by dental practitioners prevail thus calling for urgent measures towards early detection of the disease.
Background: Breast cancer is one of the common malignancies among women worldwide. Human papillomavirus (HPV) infections have been linked to many human cancers in addition to cervical cancer and one of them is breast cancer. Objective: To investigate the presence of human papilloma virus type 6 and type 11in breast cancer tissue specimens by in situ hybridization technique. Patients and Methods: Thirty four formalin-fixed, paraffin embedded tissue blocks from breast cancer patients were obtained from the archives of the pathology laboratory of Al-Yarmouk Teaching Hospital from January 2011 to July 2012. In addition formalin-fixed, paraffin embedded blocks tissue for twenty fibroadenoma of breast were collected and used as control group. In situ hybridization technique was used for the molecular detection of HPV type 6 and HPV type 11. Results: There were 82.4 % of breast cancer tissues positive for HPV type 6 and 88.2 % were positive for HPV type 11. Conclusion: The presence of human papillomavirus DNA in most breast carcinoma samples merits further investigation and confirmation by second assay in order to establish the exact role of this virus in the pathogenesis of breast cancer.
Background: Breast cancer is one of the common malignancies among women worldwide. Human papillomavirus (HPV) infections have been linked to many human cancers in addition to cervical cancer and one of them is breast cancer.Objective: To investigate the presence of human papilloma virus type 6 and type 11in breast cancer tissue specimens by in situ hybridization technique.Patients and Methods: Thirty four formalin-fixed, paraffin embedded tissue blocks from breast cancer patients were obtained from the archives of the pathology laboratory of Al-Yarmouk Teaching Hospital from January 2011 to July 2012. In addition formalin-fixed, paraffin embedded blocks tissue for twenty fibroadenoma of breast were collected and used as control group. In situ hybridization technique was used for the molecular detection of HPV type 6 and HPV type 11.Results: There were 82.4 % of breast cancer tissues positive for HPV type 6 and 88.2 % were positive for HPV type 11.Conclusion: The presence of human papillomavirus DNA in most breast carcinoma samples merits further investigation and confirmation by second assay in order to establish the exact role of this virus in the pathogenesis of breast cancer.
The diagnosis of oral cancer have been variously reported as being due to delay by clinicians, patients or both. The purpose of this study was to evaluate the referral pattern of 65 patients eventually diagnosed as having oral squamous cell carcinoma. The results showed that 50% of the patients delayed seeking professional help for more than 3 months after being aware of the lesion. The majority of the patients consulted medical practitioners as the first source of help. The mean clinicians' and patients' delay were 10.3 weeks and 28.9 weeks respectively. Dental practitioners showed a tendency to refer on more advanced lesions compared to the medical practitioners. The findings raise the concern that lack of patients' awareness, misdiagnosis by clinicians and late detection by dental practitioners prevail thus calling for urgent measures towards early detection of the disease.
Infection with Helicobacter pylori, particularly with strains positive for cytotoxicity–associated gene (CagA) gene, increases the risk of gastric adenocarcinoma and it may beassociated with carcinogenesis in extra gastric target organ. The aim of this study to explorethe possible association between CagA positive H. pylori and colorectal carcinoma anddetermine the association with clinico-pathological features.Paraffin embedded tumor specimens from (49) patients with colorectal adenocarcinoma and (30) healthy control were assessed by in situ hybridization for the expression of H. pylori CagA mRNA.Statistical analysis of H. pylori CagA positive expression revealed highly significant difference in colorectal carcinoma patients than in control group. There was no relationship between H. pylori CagA positive expression and range of clinicopathological features.Among patients infected with H. pylori CagA positive is associated with increased risk for colonic cancer.
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