No abstract

No abstract

No abstract

OBJECTIVES:The determinants of subjective well-being have been largely investigated in recent years. According to Pavot and Diener who have developed TSWL (Temporal Satisfaction with Life Scale), to assess the life satisfaction level of an individual according to temporal factors, subjective well-being is composed of two constructs: an emotional or affective component (i.e. positive and negative affects) and a conceptual or cognitive component (i.e. satisfaction with life, marriage, work, and leisure). The aim of this study was to adapt the Temporal Satisfaction with Life Scale into Turkish (TSWLS-T) and examine the reliability and validity of this new Turkish version. METHODS: The study was conducted in four phases with randomly chosen 236 participants (113 females, 123 males) and the mean age of sample was 38.6 ± 12.5 years. Cultural adaptation was implemented according to the internationally suggested method and a pretest was administered to examine the language equivalence. Since the scale had high levels of language equivalence, validity and reliability studies were conducted. For construct validity, confirmatory factor analysis was employed. The Satisfaction with Life Scale (SWLS) was used in order to evaluate the validity of TSWLS-T, since internal consistency (Cronbach's alpha and intra-class coefficients) and test-retest analysis were employed to estimate instrument reliability. RESULTS:The TSWLS-T demonstrated acceptable internal consistency, with a Cronbach's alpha of 0.87 for the total scale and ranging between 0.76 and 0.88 for the subscales. The test-retest reliability was also satisfactory, with intra-class correlation coefficients of 0.81 for the total scale and ranging between 0.61 and 0.74 for the subscales (p < 0.01). Fit indices of the model supported the factor structure. However, the 1st, 5th, and 11th items in scale (past, present, and future) showed a series of problems. With these items excluded, the 12-item model provided a better fit to the data than the 15-item model while the factor structure remained almost unchanged. The author recommends that the 12-item TSWLS be used to measure temporal life satisfaction. CONCLUSIONS: The TSWLS-T is a valid and reliable measure to assess life satisfaction in Turkish. ARTICLE HISTORY

No abstract

We aimed to investigate the role of impaired oxidant‐antioxidant homeostasis on the etiopathogenesis of autism with a novel oxidative stress (OS) marker, dynamic thiol/disulfide homeostasis (DTDH), and relationship between the symptom severity and markers. A total of 60 children with ASD aged 3–10 years and 54 unaffected children were investigated for the plasma DTDH parameters. A sociodemographic‐data form, K‐SADS‐PL, Childhood Autism Rating Scale, Abnormal Behavior Checklist, Autism Behavior Checklist, and a developmentally appropriate IQ test were administered to all participants. Distortion of DTDH to the OS‐side in the autism group was determined with lower plasma levels of native and total thiol, in contrast to a higher disulfide and thiol oxidation–reduction ratio. However, biomarkers had no correlation with the symptom severity of autism. Cutoff values for each parameter on the ROC curve might be useful to predict ASD and each DTDH biomarker was detected as an independent predictor of ASD. The present study demonstrated a disturbed redox status and absence of an expected compensatory increase in antioxidant response in a pediatric sample of ASD by measuring dynamic oxidation/reduction shifts with a novel, practical and reproducible analytical technique, and contributes to data regarding oxidative hypothesis on autism and raises the question of the place of antioxidants in autism treatment. Our results may suggest predictive usefulness of the plasma DTDH biomarkers in ASD, despite the study being conducted with a modestly small sample size that makes further research with a larger replication sample necessary to substantiate the findings. Lay Summary Dynamic thiol/disulfide homeostasis is a novel plasma marker used to determine the oxidative stress which is a natural result of disequilibrium between the oxidants and antioxidants in the human body. There is increasing interest regarding a central biological linking role of oxidative stress among the other etiological factors of autism. Our findings on the disturbed plasma dynamic thiol/disulfide homeostasis in children with autism and the absence of an expected antioxidant response against increased oxidative stress supports the data concerning the role of oxidative stress on the etiology of autism and the need of further research on the place of antioxidants in autism treatment.

Objective: There are no definitive results about either the presence of exact comorbidity between celiac disease (CD) and attention-deficit/hyperactivity disorders (ADHD) or etiology. We intend to screen ADHD-related cognitive and behavioral traits in children with biopsy-proven CD and investigate the possible association of these traits with certain vitamin levels, body-mass index, and gluten-free diet (GFD) compliance. Method: A total of 85 children with biopsy-proven CD (the ages of 8–18 years) were compared with age and sex-matched 72 healthy controls in terms of demographics, psychiatric symptoms, certain vitamin levels, and anthropometric measurements. Results: ADHD-like cognitive issues, such as inattention and learning difficulties, as well as psychosomatic symptoms and poor prosocial behavior, were all associated with GFD noncompliance in childhood CD. Conclusion: Untreated CD may predispose to ADHD-resembling symptoms. Physicians should be aware of the probability of ADHD misdiagnosing due to ADHD-resembling cognitive and behavioral traits in untreated CD.

No abstract