Sinonasal adenocarcinoma is a rare neoplasm which is classified as 'intestinal' or 'nonintestinal' type, depending on its resemblance to gastrointestinal mucosa. These tumors are associated with occupational and environmental carcinogens. In this study, a fifty-year-old oil-painter male patient with a low-grade nonintestinal type sinonasal adenocarcinoma originating from the left middle concha and ethmoid sinus is presented. Microscopical examination revealed many infiltrative glandular structures, most of which were cystically dilated and some of which were smaller in diameter, arranged back to back in loose fibrous stroma as well as intraglandular papillary and micropapillary structures forming complex branches or a cribriform pattern. The glands were lined by epithelial cells that were faintly eosinophilic and relatively abundant cubical/ cylinderical cytoplasms and mildly pleomorphic round/oval nuclei, with rare mitotic figures. Intraluminal and focally intracytoplasmic mucin was demonstrated with Alcian Blue, mucicarmin and PAS stains. Immunohistochemically, tumor cells were strongly and diffusely positive with CK7; focally and weakly positive with CK20 and negative with CDX2 in accordance with the nonintestinal type. S-100, Actin and p63, applied for investigating the myoepithelial and salivary glandular origins, were all negative. Prognostic markers, TTF-1 and p53 were negative; while the Ki-67 index was 2%. The fact that intestinal type sinonasal adenocarcinomas are generally high grade, while nonintestinal tumors are histologically low grade makes this morphological and immunohistochemical-based classification valuable in predicting the prognosis of the disease. In addition to the morphological and immunohistochemical findings, clinical information stands out in the differentiation of the tumor from benign or malignant primary lesions or metastatic adenocarcinoma.Key Words: Sinonasal adenocarcinoma, Intestinal sinonasal adenocarcinoma, Nonintestinal sinonasal adenocarcinoma, Seromucous adenocarcinoma, Low grade ÖZSinonazal adenokarsinomlar nadir olup barsak mukozasına benzerliğine göre 'intestinal' ve 'nonintestinal' olarak sınıflan-dırılmıştır. Bu tümörlerin, çevresel ve mesleki karsinojenler ile ilişkisi saptanmıştır. Çalışmamızda 50 yaşında yağlıboya ustası erkek hastada görülen sol orta konka ve etmoid sinüs kaynaklı nonintestinal tipte düşük dereceli sinonazal adenokarsinom olgusu tanıtılmaktadır. Mikroskopide hafif gevşek fibröz stromada, genellikle kistik dilate, bazıları ise daha küçük çaplı, sırt sırta yerleşmiş çok sayıda infiltratif özellikte glandların yanısıra, gland lümenlerine uzanım gösteren kompleks dallanmalar veya kribriform patern oluşturan papiller ve mikropapiller yapılar görüldü. Glandlar kübik/silindirik görece geniş sitoplazmalı, hafif pleomorfik, nadir mitoz içeren yuvarlak/oval nükleuslu tek sıralı epitelle döşenmişti. Alcian Blue, müsikarmen ve PAS ile intralüminal ve fokal intrasitoplazmik müsin gösterildi. İmmünohistokimyasal çalışmada tümör hücreleri nonintestinal ...

Peptik ülser çoğunlukla duodenum ve midede görülmektedir. Ülkemizde duodenal ülser en sık 20-50 yaş grubunda görülür iken gastrik ülser ise 30-60 yaş grubunda daha sıktır. Helikobakter pylori, aspirin ve nonsteroid antiinflamatuvar ilaçlar ülser etyopatogenezinde rol oynarlar.

Objective: Quercetin has been shown to inhibit the proliferation of cancer cells. Tamoxifen is used for breast cancer. In this study, we have aimed to investigate the effects of quercetin and tamoxifen on telomerase enzyme activity and apoptosis in two cell lines. Methods:In this study, 10, 50 and 100 µM of quercetin and tamoxifen were used to treat MCF-7 and NIH-3T3. Apoptosis was determined by the TUNEL method (Terminal Deoxynucleotide Transferase dUTP Nick End Label) and telomerase enzyme activity was determined by ELISA (Enzyme-Linked Immunosorbent Assay).Results: In the NIH3T3 cell line, only 100 µM quercetin and tamoxifen induced significant apoptosis. In the MCF-7 cell line 10 µM and 100 µM quercetin in the 24 th hour and 100 µM quercetin in the 72 nd hour induce apoptosis. In 24 th and 48 th hours, 50 µM tamoxifen and 100 µM tamoxifen in the 24 th and 48 th hours induce apoptosis in the MCF-7 cell line. In MCF-7 and NIH-3T3 cell lines, all doses of quercetin and tamoxifen reduced telomerase enzyme activity compared to the control group. Conclusion:In this study, it was shown that quercetin has similar effects to tamoxifen. However quercetin induces apoptosis more than decreasing telomerase enzyme activities, being different from tamoxifen. We hope that the findings will assist in developing new therapeutic pathways for preventing breast cancer. However, there should be many more studies in order to discover quercetin and other potential drugs.

No abstract

Peptik ülser çoğunlukla duodenum ve midede görülmektedir. Ülkemizde duodenal ülser en sık 20-50 yaş grubunda görülür iken gastrik ülser ise 30-60 yaş grubunda daha sıktır. Helikobakter pylori, aspirin ve nonsteroid antiinflamatuvar ilaçlar ülser etyopatogenezinde rol oynarlar.