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Background: Stenotrophomonas maltophilia is a Gram-negative bacillus and opportunistic emergent pathogen causing hospi- tal-acquired infections (HAIs). Due to risk factors such as prolonged intensive care unit stay and invasive procedures, it has become one of the leading causes of HAIs. Objective: The aim of this study was to evaluate the epidemiology of S.maltophilia infections over a six-year period at Düzce University Hospital, Turkey. Methods: The incidence, clinical characteristics, antimicrobial susceptibility and outcomes of nosocomial S. maltophilia in- fections during this period were retrospectively analyzed. Results: During the study period, 67 samples obtained from 61 patients were identified. Pneumonias (82%) were the most common HAIs, followed by bloodstream infections (10.5%), urinary tract infections (3%), skin and soft tissue infections (3%) and surgical site infection (1.5%). Admission to intensive care, hospitalization exceeding 30 days, and previous use of broad-spectrum antibiotics constituted risk factors. Resistance to cotrimoxazole (6%) was lower than that to levofloxacin (18%). Conclusion: The most important risk factors for S.maltophilia infection in patients are previous exposure to antibiotics, pro- longed hospitalization and invasive procedures such as mechanic ventilation. Discharging patients as early as possible with the rational use of antibiotics may be effective in reducing S. maltophilia infections and resistance rates. Keywords: Stenotrophomonas maltophilia; hospital-acquired infections; epidemiology; risk factors.

Clostridium difficile antibiyotik ile ilişkili ishal ve kolitlerin en önemli nedenidir. Dünyada önemli bir sağlık sorunu olan antibiyotik ile ilişkili ishal olgularının %15-30'undan sorumlu tutulmaktadır. Clostridium difficile enfeksiyonu hafif ishalden toksik megakolon oluşumuna kadar varan, değişken bir klinik tablo sergilemektedir İleri yaş, hastanede yatma ve özgün antibiyotiklere maruz kalma Clostridium difficile enfeksiyonu için en yaygın risk faktörleridir. Bu çalışmada uzun süre hastanede yatan hastalarda Clostridium difficile toksin A/B varlığı araştırılmıştır; bu tür bir araştırma bölgemizde daha önce hiç yapılmamıştır.