The current study was conducted to evaluate the antioxidant, Fe-chelating and lipase
inhibition activities of hydroethanolic leaf extracts of Conocarpus erectus. The proton
magnetic resonance spectroscopy (1H-NMR) was used to identify the major types of
primary and secondary metabolites in extract. The 60% ethanolic extract was found to be
the most effective fraction regarding antioxidant, Fe chelating and lipase inhibitory
properties. The 60% ethanolic leaf extract exhibited total antioxidant power of 223.0±3.27
mg ASE/g PE, β-carotene bleaching inhibition of 81.39±2.11%, Fe-chelating of
68.21±1.17% and pancreatic lipase inhibition of 50.60±1.47%, respectively. The 1H-NMR
-based prediction of metabolites provided the information for presence of polyphenolic
secondary metabolites and organic acids which might be responsible for the biological
activities of extract. These findings of this work may be extended for metabolite
characterization, in vivo trials and toxicity determination to get benefits for functional
food development with antioxidative and antiobesity attributes.
The purpose of the work was to evaluate the Fe-chelating activity of freeze drying assisted ultrasonicated hydroethanolic leaf extracts of Conocarpus lancifolius Engl. along with 1H-NMR based classification of metabolites in most active extract. The finding revealed that 60% ethanolic extract was the most active fraction regarding Fe-chelating activity with value of 75.4 ± 0.6% followed by 80% ethanolic extract having chelating value of 69.24±1.02%. The least Fe-chelating activity was exhibited by aqueous extract. The statistical analysis revealed that the Fe-chelating activity by 60% ethanolic extract was significantly higher than other fractions except EDTA which was used as standard chelating agent. The 1HNMR technique predicted the presence of aromatic secondary metabolites of polyphenolic origin due to numerous peaks in respective regions. The peaks in carbohydrate and organic acid regions were also observed. The research outcomes suggested that C. lancifolius may be workable choice to move further for the development of cure and management practices for iron load based oxidative stress oriented diseases including diabetes mellitus type II.
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