Bu çalışmanın amacı, şizofreni hastalarında içgörünün farklı boyutlarının klinik değişkenler, belirti şiddeti ve bilişsel işlevlerle ilişkisini araştırmaktır. Yöntem: Bu kesitsel tanımlayıcı çalışmada Karadeniz Teknik Üniversitesi (KTÜ) Tıp Fakültesi Psikiyatri polikliniğine ayaktan başvuran ve DSM-IV'e göre şizofreni tanısı konan 66 hasta değerlendirmeye alınmıştır. Tüm hastalar DSM için yapılandırılmış klinik görüşme (SCID-I), Pozitif ve Negatif Belirtileri Değerlendirme Ölçeği (PNBDÖ), Calgary Şizofrenide Depresyon Ölçeği (CŞDÖ), İçgörünün Üç Bileşenini Değerlendirme Ölçeği (İÜBDÖ) ile değerlendirilmiştir. Hastaların bilişsel işlevlerini değerlendirmek amacı ile Wisconsin Kart Eşleme Testi, Sözel Akıcılık Testi, İz Sürme Testi A ve B ve Rey İşitsel ve Sözel Öğrenme Testi ve Bellek testi uygulanmıştır. Bulgular: Hastaların İÜBDÖ ile değerlendirilen içgörü düzeyleri PNBDÖ pozitif, negatif, genel psikopatoloji belirti şiddeti, Sözel Akıcılık Testi ve İz Sürme Testi A ve B puanları ile ilişkili saptanmıştır. Çoklu değişkenli doğrusal regresyon analizinde PNBDÖ pozitif, Sözel Akıcılık Testi ve İz Sürme Testi A puanları İÜBDÖ toplam puanının yordayıcıları olarak tespit edilmiştir. Sonuç: Şizofrenide içgörü ile klinik belirtiler arasındaki ilişki hastalığın klinik seyrine ve psikopatoloji belirti şiddetine bağlı olarak değişebilmektedir. Bu çalışma bulguları içgörü ile bilişsel işlevler arasındaki ilişkide frontal yürütücü işlevlerin önemini vurguluyor olabilir.
The purpose of this study is to examine the factors which influence schizophrenia patients' levels of insight and functional remission. Method: In this study, 70 outpatients between the ages of 18-65 who applied to the Karadeniz Technical University Psychiatry Clinic and were diagnosed with schizophrenia according to DSM-IV were evaluated. Patients who have disease which affects the central nervous system, whose CGI disease severity score is above four, who were taken as inpatients to the hospital in the last two months were excluded from the study. The patients were evaluated by using socio-demographic data collection form, clinical interview structured for DSM (SCID-I), the Positive and Negative Syndrome Scale (PANSS), Calgary Depression Scale (CDS), the Functional Remission of General Schizophrenia Scale (FROGS), Schedule for Assessing the Three Components of Insight (SAI-E) and cognitive test battery. Results: Patients SAI-E levels were found to be correlated with the PANSS, Stroop Test (ST), Controlled Word Association Test (FAS) and Trail Making Test (TMT) A-B scores. In the regression analysis, FAS scores were the predictor of SAI-E total scores .The FROGS functional levels of patients were found to be related with occupational status, gender, age of onset illness, comorbid psychiatric illness, PANSS, CDS, SAI-E, FAS, TMT, ST and Wisconsin Card Sorting Test scores. In the regression analysis, occupational status, comorbid obsessive compulsive disorder, PANNS negative and general psychopathology and FAS scores were the predictors of patients' functional status. Discussion: The effect of cognitive functioning and insight on the patients' level of functionality is prominent.
Background Whether the false memory dysfunction in schizophrenia is at the early (encoding, perceptual) or later (retrieval) stages and how delusions affect it remains unclear. Method In this study, we examined the perception and memory biases in schizophrenia patients with (Sch/D; n = 31) and without delusions (Sch/Nd; n = 32) and compared them with healthy controls (HCs; n = 35). We used the Deese Roediger McDermott (DRM) Paradigm and the Noise Task to measure the false memory and illusory pattern perception (IPP) biases, respectively. Results We found that the patient groups performed lower in both the recall and recognition phases for the DRM and the Noise tasks and made more errors compared to the HC group. Additionally, the performance of the Sch/D group was remarkably lower than the Sch/Nd and HC groups. Conclusions Our results indicated that the information-processing problem in schizophrenia exists in both the encoding and retrieval stages. Also found significant relationship between the presence of delusions and the increase in cognitive deficits. Supplementary Information The online version contains supplementary material available at 10.1007/s10608-023-10393-6.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.