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Cutaneous leishmaniasis, is common parasitic disease in Iraq, it is caused by unicellular protozoa that belong to the genus Leishmania which infecting human macrophages, and  it is induce human humoral and cellular immune responses. Many cytokines are excreted during this response, however IFN -γ and TNF -α  are the most important factors in the inception of immunity against leishmania spp. The present study aimed to estimate the serum level of TNF-α and IFN-Ƴ in patients with cutaneous leishmaniasis (CL) by enzyme-linked immunosorbent assay (ELISA). Out of 62 patients with CL lesion the infection rate was higher in males 36 (58%) than females 26 (42%), also the highest infection rate 29 (46.8%) was in age group (less than 1 -10years), and the lowest infection rate 18 (2.4%) was in the age group (51-60). Blood samples collected from 62 patients with CL and 27 healthy individual. The results showed that the level of serum IFN-Y (38.23 pg/mL) in patients with CL was significantly higher than control group (21.98 pg/mL). As well as the results indicated a significantly increase in the  levels of  TNF-α in patients serum with CL (46.53 pg / mL) than control group (23 pg / ml).

To evaluate the serum concentrations of proinflammatory cytokines interleukin (IL-1, IL-6, IL-8, IL-18), tumour necrosis factor α (TNF-α), C-reactive protein (CRP), and antiinflammatory cytokine interleukin 10 (IL-10) regulatory in patients with AMI, and to assess the correlation between anti-inflammatory and pro-inflammatory cytokines in AMI. Thirty patients (13 women and 17 men) with (AMI) enrolled in this study and 30 as control group (10 women and 20 men). There aged varied between 40-60 years old. In this study were measured serum levels of proinflammatory cytokines interleukin (IL-6, IL-1, IL-18, and IL-8), TNF-α, and anti-inflammatory cytokine interleukin 10 (IL-10) in both patient and in control groups by using ELISA technique.

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