Twenty-two consecutive patients with malignant diffuse pleural mesothelioma were treated with recombinant gamma-interferon by the intrapleural route. Diagnosis was made by thoracoscopic examination and all cases were confirmed by the French Mesothelioma Panel of Pathologist. Patients were staged based on thoracoscopic examination and computed tomography (CT) scan: 12 patients were classified as Stage I and 10 were Stage II. A solution of gamma-interferon (40 X 106 U) was infused twice a week over 2 months. Every patient experienced fever. One patient had a Grade 2 leukopenia and one patient suffered from pleural empyema. Response evaluation was based on the following: (1) CT scan performed 2 weeks after treatment ended, and (2) repeat thoracoscopic examination with histopathologic verification in nine patients who had demonstrated a stabilization or a regression of the disease on CT scan. From the original group, 19 patients could be evaluated. Four complete thoracoscopic histopathologic responses and one partial response were observed in Stage I patients (56%). One partial response was observed in Stage II patients.

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Background: Recurrent Pregnancy Loss (RPL) is defined as the occurrence of three (or) more clinically recognised pregnancy losses before 20 weeks of gestation. Spontaneous abortions occur in 15% of clinically recognised pregnancies in reproductive age group women. Hyper homocysteinemia has been associated with clinical vascular thrombosis and this could be the cause for early decidual and chorionic vessel damage that might result in disturbed implantation of the conceptus. Aim: To determine the plasma homocysteine levels in patients with polycystic ovarian syndrome (PCOS) having recurrent pregnancy loss (RPL) compared with women with PCOS who had uneventful pregnancies and assess the role of hyper homocysteinemia for RPL in PCOS. Materials and Methods: This is a case-control study on 20 PCOS women with RPL and 20 control PCOS women with uneventful pregnancies matched by age, marriage duration and body mass index(BMI). Plasma homocysteine levels were assessed from Feb, 2013 to Feb, 2014. Results: The mean plasma homocysteine in the cases and controls were 19.10±1.01 and 16.41±1.24 (p=0.0001). The difference in the homocysteine levels was found to be statistically significant. Conclusion: Risk of RPL in patients with PCOS is increased with hyperhomocysteinemia (p< 0.0001).