All 23 patients treated for juvenile laryngeal papillomatosis (JLP) in the Copenhagen region during a 4-year-period were identified for this epidemiological study. The incidence of JLP was 0.6/100,000 among the population at risk, children aged 0-14 years, and the prevalence was 0.8/100,000. It is concluded that the condition in most cases has a good prognosis, i.e., short duration and low morbidity. Only in a few cases JLP will take a long-lasting course. Regression before or during puberty does not in all cases ensure complete recovery. Thus, 7 of 12 adult patients experienced a quiescent period of 21 years (median). Spread of papillomas to the bronchogenic system seems to be a serious prognostic sign.
All patients treated for laryngeal papillomas with adult onset in the Copenhagen region during a 4-year period were identified for this epidemiological study. The incidence was 0.8/100,000 among the population at risk and the prevalence was 2.3/100,000. It is concluded that papillomas with juvenile and adult onset are one and the same disease and that single papillomas versus multiple papillomas cannot be considered different entities. As is the case with juvenile laryngeal papillomas, the prognosis is good and the morbidity low in most cases of adult onset papillomas, but malignant degeneration must be considered a risk factor.
Parameters of importance for the development of thrombosis were investigated in a patient with polyarteritis nodosa (PAN) and profound sensorineural hearing loss. During the acute phase, platelet hyperaggregability, shortened platelet survival, and decreased fibrinolytic activity were found. The possibility is discussed that the etiology of the acoustico-vestibular symptoms in this patient could be an inner ear thromboembolic disorder. It is suggested that platelet functions and fibrinolytic activity should be investigated in patients with acoustico-vestibular symptoms and PAN or other systemic diseases. If abnormalities are found, specific platelet inhibitory and/or fibrinolysis-increasing treatment should be considered as an addition to the conventional medical treatment.
In a consecutive series of 11 young patients with clinical evidence of cerebral infarction, platelet function and plasma lipid levels were examined. The results show that incrcascd platelet aggregability characterizes the patient group as a whole. Hgperlipidemia was frequently found, and the number of heavy smokers was high. It is suggested that all younger patients with cerebrovascular disease are examined with regard to these presumed risk factors.
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