Juvenile laryngeal papillomatosis. An epidemiological study from the Copenhagen region

Abstract

All 23 patients treated for juvenile laryngeal papillomatosis (JLP) in the Copenhagen region during a 4-year-period were identified for this epidemiological study. The incidence of JLP was 0.6/100,000 among the population at risk, children aged 0-14 years, and the prevalence was 0.8/100,000. It is concluded that the condition in most cases has a good prognosis, i.e., short duration and low morbidity. Only in a few cases JLP will take a long-lasting course. Regression before or during puberty does not in all cases ensure complete recovery. Thus, 7 of 12 adult patients experienced a quiescent period of 21 years (median). Spread of papillomas to the bronchogenic system seems to be a serious prognostic sign.

Prevention of recurrent respiratory papillomatosis: Role of HPV vaccination

“…The risk of transmitting the disease is estimated as 200-400-fold increase compared to a child delivered to a woman without condyloma [4]. This is a rare disease with nationwide estimates of pevalence ranging from 80 to 2300 cases [5,6]. There is similar estimates of prevalence 0.8/100,000 cases reported in European studies as well [7].…”

Clinical Course of Recurrent Respiratory Papillomatosis in Danish Children

“…7,10,13,20,21 Armstrong et al 7 in the most recent and largest study were the only researchers to examine age and disease duration concurrently. They found that children with an age of onset younger than 3 years were 3.6 times more likely than children diagnosed at older ages to have more than 4 surgical procedures per year.…”

The incidence and prevalence of juvenile-onset recurrent respiratory papillomatosis in the Free State province of South Africa and Lesotho

“…The infection is believed to be acquired from the mother's genital tract during the birthing process [1]. Although the estimated incidence and prevalence of JORRP has been determined in countries in North America and Europe and in Australia [2][3][4][5][6][7][8][9][10], there have not been any studies that have attempted to determine the incidence or prevalence of JORRP in African countries.…”