The 2007 Accreditation Council for Pharmacy Education (ACPE) Accreditation Standards and Guidelines for the Professional Program in Pharmacy delineate new expectations for experiential education within curricula and include guidance on the development and conduct of Pharmacy Practice Experiences. The American College of Clinical Pharmacy (ACCP) Educational Affairs Subcommittee C developed a position statement to further delineate the views of ACCP on factors necessary to meet contemporary standards for doctoral education in pharmacy and to provide guidance to our membership on how to implement the new standards. This White Paper provides explanation and supporting documentation for positions on quantitative and qualitative aspects of experiential education, as well as requirements for practice sites, preceptor roles, qualification, credentialing, and development and assessment of student performance.

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The relationship between serum haloperidol concentration and improvement in abnormal movements was investigated in 20 adult Huntington's disease (HD) patients. Serum samples and assessments of severity of chorea were simultaneously obtained from each patient. Data were obtained prior to and at one or more doses following the initiation of haloperidol in ten patients. Serum was analyzed for haloperidol by two different methods, gas chromatographic/mass spectrometric (GC/MS) and radioreceptor (RR) assays. Steady-state serum haloperidol concentrations (GC/MS) of 0.5 to 24 ng/ml were observed following administration of doses of 1 to 40 mg/d and varied markedly between patients. Only results from the GC/MS assay were used for examining relationships with dose and clinical response because of insensitivity of RR assay. Significant improvement of abnormal movements, greater than 30% from baseline, occurred at serum concentrations between 2 and 5 ng/ml, which corresponded to doses of 1.5 to 10 mg/d. Further improvement in abnormal movements at serum concentrations above this range was minimal.

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We evaluated the effect of food on the serum concentration profile of enteric-coated divalproex sodium (EC-VPA) in six adult volunteers following a single dose and in six patients during chronic-dose administration. The results demonstrated a significant delay but no decrease in extent of EC-VPA absorption following administration with food. To monitor serum concentrations in patients receiving EC-VPA, consideration of sampling time in relation both to time of dose and meals is required.

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Following metrizamide myelography, this patient transiently developed quadriparesis, complete loss of reflexes, and disappearance of upper motor neuron signs. Unlike previous cases reported by and Buruma and Hekster [ 3 ] , the weakness and areflexia in our patient were generalized. I t is uncertain whether the impairment was mediated at the level of the ventral roots, anterior horn cells, or corticospinal tracts. Damage to any of these structures could lead to a picture resembling "spi- A 52-year-old woman with a twenty-year history of hypertension, diabetes mellitus for two years, and mild chronic renal failure was seen 12 days after developing violent Hinging movements of her right arm. Physical examination showed choreoathetoid movements with frequent flinging movements involving the right arm. H e r right leg showed only occasional choreoathetoid movements. The movements increased under stress, were absent during sleep, and were diminished somewhat by voluntary activity. There was no alteration in reflexes or muscle tone. T h e rest of the neurological examination was within normal limits. Computerized tomographic scan of the head was normal. Sodium valproate was given at a close of 250 mg orally four times a day, and within 12 hours all abnormal movements disappeared. The patient received a total of ten doses of sodium valproate, after which a similar placebo capsule was substituted for 24 hours. Abnormal movements did not reappear.The observed recovery in this case could have been spontaneous, but the abruptness of the response speaks against it. The similarity in response between our patient and the one reported by Lenton et a1 [

Treatment of post-traumatic choreoathetosis with sodium valproate Sir: We report a study which establishes the efficacy of sodium valproate in the treatment of post-traumatic choreoathetosis.