Treatment of post-traumatic choreo-athetosis with sodium valproate.

Chandra, Vijay; Spunt, Avery L.; Rusinowitz, M S

doi:10.1136/jnnp.46.10.963

Cited by 21 publications

(5 citation statements)

References 4 publications

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“…Despite rare reports of chorea secondary to its use, valproate can improve chorea, such as post-traumatic choreoathetosis [136], 'senile' chorea [137], hemiballismus of vascular origin [138], and particularly Sydenham's chorea [139], as confirmed by small series showing sustained and dramatic effects within a few days from treatment initiation [140].…”

Section: Valproatementioning

confidence: 99%

Antiseizure Drugs and Movement Disorders

Sáenz‐Farret

Tijssen

Eliashiv³

et al. 2022

CNS Drugs

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The relationship between antiseizure drugs and movement disorders is complex and not adequately reviewed so far. Antiseizure drugs as a treatment for tremor and other entities such as myoclonus and restless leg syndrome is the most common scenario, although the scientific evidence supporting their use is variable. However, antiseizure drugs also represent a potential cause of iatrogenic movement disorders, with parkinsonism and tremor the most common disorders. Many other antiseizure drug-induced movement disorders are possible and not always correctly identified. This review was conducted by searching for all the possible combinations between 15 movement disorders (excluding ataxia) and 24 antiseizure drugs. The main objective was to describe the movement disorders treated and worsened or induced by antiseizure drugs. We also summarized the proposed mechanisms and risk factors involved in the complex interaction between antiseizure drugs and movement disorders. Antiseizure drugs mainly used to treat movement disorders are clonazepam, gabapentin, lacosamide, levetiracetam, oxcarbazepine, perampanel, phenobarbital, pregabalin, primidone, topiramate, and zonisamide. Antiseizure drugs that worsen or induce movement disorders are cenobamate, ethosuximide, felbamate, lamotrigine, phenytoin, tiagabine, and vigabatrin. Antiseizure drugs with a variable effect on movement disorders are carbamazepine and valproate while no effect on movement disorders has been reported for brivaracetam, eslicarbazepine, lacosamide, and stiripentol. Although little information is available on the adverse effects or benefits on movement disorders of newer antiseizure drugs (such as brivaracetam, cenobamate, eslicarbazepine, lacosamide, and rufinamide), the evidence collected in this review should guide the choice of antiseizure drugs in patients with concomitant epilepsy and movement disorders. Finally, these notions can lead to a better understanding of the mechanisms involved in the pathophysiology and treatments of movement disorders.

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Section: Valproatementioning

confidence: 99%

Antiseizure Drugs and Movement Disorders

Sáenz‐Farret

Tijssen

Eliashiv³

et al. 2022

CNS Drugs

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“…46 In the following years, several cases and case series reporting efficacy of valproate for chorea related to various etiologies were published. [47][48][49][50][51][52][53][54][55] In a retrospective comparison study by Pena et al, 29 valproic acid was found to be more effective than carbamazepine and haloperidol. Genel et al 56 prospectively compared valproic acid and carbamazepine and reported that they are equally effective and safe.…”

Section: Antiepileptic Drugsmentioning

confidence: 99%

Treatment of Chorea in Childhood

Yılmaz

Mink

2020

Pediatric Neurology

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“…The anticonvulsant sodium valproate has been used effectively to treat Sydenham chorea in children 16 , 17 as well as the choreiform movements seen in other disorders such as posttraumatic choreoathetosis, 18 kinesiogenic familial paroxysmal choreoathetosis, 19 hemibal‐lismus, 20 , 21 and myoclonus 22 , 23 . Sodium valproate has not been effective in the treatment of Huntington disease 24 , 25 .…”

Section: Discussionmentioning

confidence: 99%