Kastoba Lake in Bawean Island Indonesia is a tourist attraction that has a level of vulnerability in landslide disasters. The landslides has been happen. From the large and small scale in the Kastoba Lake. Base on the problem, the landslides occured due to the field of derailment. According to the above statement, it was necessary to know the subsurface structure and the field of avalanche derailment in the kastoba lake area. This data was allowed by geophysical resistivity method which a dipole-dipole configuration with 4 measurement points. The acquisition of data was based on preliminary studies from the analysis of landslide vulnerability level maps (DEM Alos data processing) that have been done first. The results of lithological analysis with geoelectric resistivity methods in this research obtained three layers of subsurface structure, namely top soil (top layer) with a resistivity value of 7-110 Ωm, clay (middle layer) which was a resistivity value of 110-210 Ωm and lava (bottommost layer) which was a resistivity value of 210-357 Ωm. The field of gelincir in the research area was on the top layer of soil composed of weathering of rocks mixed with organic material or leaf/tree decay with an average depth of 7.25 meters. Thus, this research can be one of the parameters of landslide disaster mitigation in the development of geotourism in Kastoba Lake
AbstrakUrtikaria merupakan lesi kulit yang terdiri dari reaksi wheal dan flare. Sebanyak 15-20% penduduk pernah mengalami urtikaria dalam kehidupannya, dan 25% diantaranya mengalami urtikaria kronik. Kejadian urtikaria lebih banyak dijumpai pada perempuan. Adanya hubungan antara proses imunologis dan aktivitas neuroendokrin menjadi salah satu hipotesis yang mendasari patogenesis urtikaria. Ditemukannya peran DHEAS dalam fungsi imunomodulator dan antiinflamasi dapat menjadi dasar adanya peran dari terganggunya fungsi DHEAS akibat defisiensi dengan proses inflamasi pada urtikaria. Rancangan penelitian observasional potong lintang dilakukan untuk mengetahui adanya hubungan antara kadar hormon dehidroepiandrosteron sulfat (DHEAS) serum dengan aktivitas penyakit urtikaria kronis pada perempuan. Hasil uji Kruskall Wallis dengan post hoc Man Whittney menunjukkan adanya perbedaan yang bermakna antara aktivitas penyakit urtikaria dengan kadar DHEAS serum (p = 0,000). Analisis uji Spearman menunjukkan adanya korelasi negatif yang kuat antara aktivitas penyakit urtikaria dengan kadar DHEAS serum (r = -0,933; p = 0,000). Hal ini menunjukkan bahwa pada kadar yang lebih tinggi maka hormon DHEAS dapat bersifat protektif terhadap perburukan klinis urtikaria, dan sebaliknya pada kondisi urtikaria yang kronis terjadi penurunan kadar hormon DHEAS serum. Dapat disimpulkan bahwa pada wanita, ada hubungan antara kadar DHEAS serum dengan aktivitas penyakit urtikaria kronis. Hasil ini memperkuat kemungkinan terjadinya penurunan kadar DHEAS serum yang berperan dalam patogenesis urtikaria kronis.Kata kunci: aktivitas penyakit, dehidroepiandrosteron sulfat serum, urtikaria kronis SERUM LEVEL OF DEHYDROEPIANDROSTERONE SULFATE (DHEAS) AND THE RELATIONSHIP WITH CHRONIC URTICARIAL IN WOMEN AbstractUrticaria is a skin lesion consisting of wheal and flare reaction. As many as 15-20 % of the population had experienced urticaria in their lives, and 25% had chronic urticaria. Urticaria is more common in women. The relationship between immunological and neuroendocrine activity became one hypothesis underlying the pathogenesis of urticaria. The role of DHEAS in the immunomodulatory and antiinflammatory effects underline the role of DHEAS deficiency in the pathogenesis of urticaria. A cross-sectional observational study design was conducted to determine the relationship between serum levels of dehydroepiandrosterone sulfate (DHEAS) with disease activity in women with chronic urticaria. The statistical analysis using Kruskall Wallis test with posthoc Man Whittney showed significant difference between urticaria disease activity with serum DHEAS levels (p = 0.000). The correlation analysis using Spearman test showed a strong negative correlation between disease activity of urticaria with serum DHEAS level (r = -0,933; p = 0,000). This results suggest that higher level of DHEAS may be protective against clinical worsening of urticaria. In the other hand, in chronic urticaria condition, the level of DHEAS will be decline. It can be concluded, there is a r...
Tuberous Sclerosis Complex (TSC) is an autosomal dominant inherited neurocutaneous disorder. Tuberous Sclerosis Complex is caused by mutations in tumor suppressor gene (TSC), both TSC1 and TSC2. In approximately two-thirds of cases neither parent has signs of TSC and the disease is caused by a de novo mutation. Tuberous Sclerosis Complex is classically identified by the Vort's triad in the presence of angiofibroma, mental retardation, and epilepsy. A 17-year-old woman with a major complaint of a facial bump that appeared at birth and got bigger when she reached puberty. There are white patches on the patient's body from birth. On the scalp obtained the presence of skin color plaque, while at the back and right knee obtained shagreen patch. Patientwas diagnosed with epilepsy and mental retardation by the pediatric department. No family history has the same complaints as patient. Histopathologic examination of facial bumps taken by shaving biopsy suggests the presence of hemangiomas. Based on the clinical diagnostic criteria from International Tuberous Sclerosis Complex Consensus Conference 2012, the patient meets two major criteria, macular hypopigmentation and shagreen patch so it is included in "definite diagnosis".
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