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The roots of Cephalaria gigantea (LEDEB.) BOBROV (Dipsacaceae), an endemic plant of Caucasus growing in Georgia, 1) contain a large amount of triterpene saponins. 2-4) The roots are well-known in traditional medicine as sedative and anti-inflammatory remedies.1) Previous works reported the identification of six triterpene glycosides. 5,6) Antifungal and antiprotozoal activities of giganteosides D and E, major monodesmosides, have been evaluated.7) The present paper describes isolation and structure elucidation of three new triterpene saponins, named giganteosides L (1), M (2) and N (3) from the roots of Cephalaria gigantea. Their structures were established on the basis of 2D-NMR experiments (gs-COSY, gs-HMQC, gs-HMBC and gs-HSQC-TOCSY) and mass spectrometry (MALDI-TOF, ESI-HR-MS). Saponins containing glucuronic acid in the sugar chain are reported for the first time in Cephalaria species. In addition, eight known triterpene glycosides, giganteosides D (4), 5) E (5), 5) G (6), 6) H (7), 6) I (8), 8) K (9), 8) J (10) 9,10) and J 1 (11) 9,10) were isolated from this plant.Dried root of C. gigantea was extracted with boiling 80% MeOH and after filtration the solution was evaporated. The solid residue was dissolved in methanol and precipitated in acetone. A combination of low pressure liquid chromatography and repeated silica gel column chromatography allowed the purification of eleven glycosides (1-11) including three new ones. The structures of the new saponins (1-3) were established on the basis of acid hydrolysis, NMR (Tables 1, 2)

Terpenes U 0200 Antimalarial Activity of Sesquiterpene Lactones from Vernonia cinerea. -The new sesquiterpene lactones vernolide C (Ia) and D (Ib) and six known analogues are isolated from the dichloromethane fraction of an aqueous extract. -(CHEA, A.; HOUT, S.; LONG, C.; MARCOURT, L.; FAURE, R.; AZAS, N.; ELIAS*, R.; Chem.