Screening of selected indigenous plants of Cambodia for antiplasmodial activity

Hout, Sotheara; Chea, Aun; Bun, Sok-Siya; Élias, Riad; Gasquet, M.; Timon‐David, P.; Balansard, G.; Azas, Nadine

doi:10.1016/j.jep.2006.01.028

Cited by 76 publications

(73 citation statements)

References 33 publications

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“…Phyllanthus urinaria was mentioned in this study as being used to manage and treat high blood pressure, malaria, sore throat, and ulcer. The antiplasmodial activity of Phyllanthus urinaria has been well known [136,137]. Hippomanin A and corilagin isolated from P. urinaria were found with in vitro antiviral activity [138].…”

Section: Potential Allelopathic Effects Of Volatile Constituents Frommentioning

confidence: 99%

Exploring Alternative Use of Medicinal Plants for Sustainable Weed Management

et al. 2017

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This paper presents the first application of ethnobotanical studies to screen for allelopathic species among medicinal plants for sustainable weed management. This study assesses the possible relationship between ethnobotanical indices and allelopathy of medicinal plants. Ethnobotanical data were collected in 2016 by using semi-structured interviews with 140 informants in the Ejisu-Juaben Municipality, Ghana. Data were analysed using statistical tool and ethnobotanical indices including use value (UV), Fidelity Level (FL), Relative Frequency of Citation (RFC). The Sandwich and Dish pack methods were respectively used to evaluate allelopathy through leachates and volatiles of collected samples. Ninety-five species belonging to 43 families are reported in this study, with leaves (52%) cited the most utilised plant part. Cleistopholis patens (UV = 0.54; FL = 90.7%; RFC = 0.37) and Ocimum gratissimum (UV = 0.37; FL = 38.4%; RFC = 0.35) were among the most cited species. Thirty-two species showed inhibition (≥49.3%) by leachates, while twenty-four species were found with potential volatile inhibitory compounds against lettuce radicle growth. There was a significant positive correlation (Pearson) between the UV and RFC of medicinal plants and allelopathy by leaf leachates (r = 0.639 **; p = 0.01 and r = 0.653 **; p = 0.01 respectively). This systematic documentation of medicinal plants in Ejisu-Juaben Municipality shows medicinal plants with ethnomedicinal values and potential allelopathy that can be utilised in sustainable weed control.

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Section: Potential Allelopathic Effects Of Volatile Constituents Frommentioning

confidence: 99%

Exploring Alternative Use of Medicinal Plants for Sustainable Weed Management

et al. 2017

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“…(Menispermaceae) is an indigenous Cambodian wild plant that is commonly used in traditional food and medicine such as the treatment of fever and as a tonic 15 . Stephania rotunda has been chemically investigated and found to contain alkaloids such as rotundine, tuduranine, cepharamine, tetrahydropalmatine, and cycleanine [16][17][18][19][20] .…”

Section: Introductionmentioning

confidence: 99%

Antioxidant activity of bisbenzylisoquinoline alkaloids from Stephania rotunda: cepharanthine and fangchinoline

Gülçın

Élias²,

Gepdíremen

et al. 2009

Journal of Enzyme Inhibition and Medicinal Chemistry

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126

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“…Salah satu tumbuhan di Pulau Lombok yang diketahui memiliki aktivitas antidiabetes yang cukup tinggi berdasarkan pengalaman empiris masyarakat di daerah Sesaot (Kecamatan Narmada, Kabupaten Lombok Barat) adalah biji buah makasar (Brucea javanica (L.) Merr) (Okuyama et al, 1990). Tanaman ini dikenal juga dengan "Tanaman Wali" karena dipercaya memiliki aktivitas antidiabetes (Ablat et al, 2014), disamping aktivitas lainnya seperti antikanker (Sakaki, et al, 1986) dan antimalaria (Hout et al, 2006). Ablat et al, (2017) melaporkan fraksi etanol dan etil asetat ekstrak etanol biji buah makasar dapat menurunkan kadar gula darah mencit diabetes dan menghambat aktivitas enzim α-glukosidase.…”

Section: P E N D a H U L U A Nunclassified

EFEK HIPOGLIKEMIK INFUSA DAUN TANAMAN MAKASAR, <em>Brucea javanica</em> (L) Merr, PADA TIKUS HIPERGLIKEMIK YANG DIINDUKSI ALOKSAN

2017

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A B S T R A C TBrucea javanica (L) Merr is a local plant used traditionally for diabetic medication in Lombok Island. The B. javanica seed has been recognized to have an antidiabetic effect, while the impact of the leave extract was understudied. The purpose of this research was to determine the effect of B. javanica leaves infusion on the blood glucose level of alloxan-induced diabetic rats. B. javanica leaves extract were applied by soaking leaves into hot water (95°C) to obtain the extract concentration of 5% (w/v). This experiment provides four treatments to rats within 15 days with five replicates for each treatment. The treatments for rats were K1 a positive control, K2 a negative control, K3 a healthy control, and P1 treated with leave infused water. The diabetic condition for K1, K2, and P1 was induced with an intravenous injection of 125 mg/kgBW alloxan monohydrate to the rats. After stable diabetic condition, K1 rats were treated with Glibenclamide (0,25 mg/kgBW), K2 rats were untreated, P1 rats were administered with leaves infused water of B. javanica (L) Merr 3 ml/day. K3 rats were uninduced and untreated. The hypoglycemic effect was observed by estimating the fasting blood glucose level of the rats every three days. After 15 days of treatments, P1 rats blood glucose level reduced by the 13,30%, while K1 rats 22,04%. The decrease in blood glucose level of both K1 and P1 rats have not reached the average blood glucose level of healthy rats. The result of the statistical analysis showed the infused extract effect was not significantly differed compared to positive control (P < 0.05).KEY WORDS: hypoglycemic effect, Brucea javanica (L) Merr, infused extract, alloxan, hyperglycemic rat Penulis korespondensi: HANDA MULIASARI |

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Screening of selected indigenous plants of Cambodia for antiplasmodial activity

Cited by 76 publications

References 33 publications

Exploring Alternative Use of Medicinal Plants for Sustainable Weed Management

Exploring Alternative Use of Medicinal Plants for Sustainable Weed Management

Antioxidant activity of bisbenzylisoquinoline alkaloids from Stephania rotunda: cepharanthine and fangchinoline

EFEK HIPOGLIKEMIK INFUSA DAUN TANAMAN MAKASAR, <em>Brucea javanica</em> (L) Merr, PADA TIKUS HIPERGLIKEMIK YANG DIINDUKSI ALOKSAN

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