<p>Fish oil has been studied for medicinal purposes, including its antipyretic properties. Eel (<em>Anguilla bicolor bicolor</em>) oil, which contains vitamins and fatty acids, including Omega-3 (EPA and DHA), is also expected to have the antipyretic effect. This research aimed to examine the antipyretic activity of eel oil on white mice (<em>Mus musculus</em> L.). An in-vivo study was done on thirty Swiss-Webster strain males mice that previously got 20% yeast-induced fever. Six treatments were applied including normal group (untreated), a negative control group (yeast-treated), a positive control group treated with acetaminophen (1.764 mg/20 g body weight), and three groups treated with eel oil (0.048, 0.096 and 0.192 g/20 g body weight, respectively). The data was analyzed statistically using one way ANOVA then was continued with LSD post hoc test. The results showed that eel oil has significantly reduced yeast-induced hyperthermia on mice five hours after application at doses 0.096 and 0.192 g/20 g body weight. Our finding suggests that eel oil possess antipyretic properties when was applied in certain doses, and this effect is presumably attributed to its high content of fatty acid, including EPA and DHA.</p>
Iota-carrageenan, a water-soluble polymer extracted from red seaweed, Eucheuma denticulatum, showed a high potentiality as a film-forming material. Whilst, one of the essential oils that gained increasing attention is from cinnamon because of its recently observed antimicrobial and antioxidant properties. In this study, mechanical and water barrier properties of semi-refined iota-carrageenan (SRiC)-based edible film incorporated with cinnamon essential oil were evaluated into two stages. Firstly, the effects of sorbitol plasticizer’s concentration (0.5%, 1.0%, 1.5% v/v) on the mechanical and water barrier properties of the SRiC-based edible film (2% w/v) was investigated, and secondly, those of cinnamon essential oil’s incorporation (0.5%, 0.75%, and 1.0% v/v) were evaluated. SRiC (2% w/v) produced with 0.5% (v/v) sorbitol plasticizer addition was selected for the first stage, and 1% (v/v) cinnamon essential oil incorporation on SRiC-based edible film was recommended for the second, suggesting its further utilization in food application.
Analgesic and anti-inflammatory tests of eel (Anguilla bicolor bicolor) oil on animal models have been performed. Previous studies have proven that oral administration of EPA and DHA exhibits analgesic and anti-inflammatory effects. Gas Chromatography analysis shows that eel contains EPA and DHA. In this research, the analgesic activity was evaluated with the acetic acid-induced writhing test and hot plate test, while the anti-inflammatory properties were identified using carrageenaninduced inflammation. In the writhing test, 25 male Swiss Webster mice were divided into five groups. Group I was given 0.5% CMC-Na as a negative control, group II was given 65 mg/kg b.w. of Acetosal as a positive control, group III-V was given eel oil at different doses, namely 2400, 4800, and 9600 mg/kg b.w. of the mouse. For the hot plate test, 6.5 mg/kg b.w. of tramadol acted as the positive control. Similar to the analgesic effect analysis, the anti-inflammatory test also divided 25 male Wistar rats into five groups. Group I as a negative control was given 0.5% CMC-Na, group II was given 9 mg/kg b.w. of diclofenac potassium as a positive control, and group III-V were given eel oil at different doses, namely 1500, 3000, and 6000 mg/kg b.w. of the rat. The results of the acetic acidinduced writhing test and hot plate test showed that when compared with the positive and negative controls, eel oil had a potential analgesic activity with a significance value of p< 0.05. The analgesic effects were noticeable at doses of 2400, 4800 and 9600 mg/kg b.w. in the writhing test and at 4800 and 9600 mg/kg b.w. in the hot plate test. The anti-inflammatory test showed that eel oil was efficacious when administered at the doses of 1500, 3000, and 6000 mg/kg b.w. with percentage inhibition of 34.35%, 35.132%, and 40.28%, respectively.
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