Acromegaly is described as a less common chronic disease occursas a result ofover secretion of growth hormone (GH) often from a pituitary adenoma; it is connected to noticeable morbidity and increased mortality. Our study aimed to determine calcium (Ca) and vitamin D status inacromegalic patients regarding disease activity and estimating the relationship between vitamin D, IGF-1 and some biochemical parameters. Correlations of vitamin D with IGF-1, BMI, Ca, GOT, GPT, ALP, T3, T4, TSH, urea and creatinine were studied. The study groups comprise of 50 male, 25 acromegalic patients and 25 control male groups. The results of vitamin D measurements showed a decrease levels of vitamin D in all acromegalic patients and this revealed that patients with acromegaly have a high significant decrease (p < 0.001) of BMI, IGF-1, vitamin D, Ca, GOT and creatinine compared to control group, while significant increase for GPT, ALP, T3, T4 and urea for patients with acromegaly. However, the results showed a highly positive significant association between vitamin D and BMI, IGF-1, urea, creatinine and T4 levels, whereas demonstrated a highly significant positivecorrelation of vitamin D levels with GOT and ALP, also the results showed non-significant difference between vitamin D, Ca and T3 with a negative correlation with TSH also asignificant positive correlation between vitamin D and GPT appeared. We concluded that acromegalic patients were suffering from low vitamin D levels compared to the controls group and also suffering from lower kidney activity (hydroxylation at the position of 25-OH-D3 site) and this is evident from the high creatinine levels in the blood, which leads to the non-activation and even low levels of vitamin D and therefore acromemglic patients will suffer from vitamin D deficiency high risk thus the treatment procedures for acromegaly should include doses of active vitamin D, which reduces the risk of this deficiency.
Background The deficiency of vitamin D3 (VD) is a universal health issue, its role in different kind of diseases is being studied recently. However, its role in thyroid diseases is not well established yet. This study aims to determine the impact of VD in the pathogenesis of hypothyroidism and hyperthyroidism. Method. Three hundred Iraqi females with age ranged between 30 and 55 years participate in this research, 100 of them were hypothyroid patients, 100 females were hyperthyroid patients and the other 100 females were healthy volunteers served as controls. Thyroid hormones, VD, liver function parameters, and kidney function parameters were determined using different analysis techniques. Results. The levels of VD were significantly decreased in both hypothyroid and hyperthyroid patients (19.644 ± 10.524 for hypothyroid patients and 22.712 ± 11.249 for hyperthyroid patients vs. 30.880 ± 2.587 for controls, p <0.0001). Liver function parameters were within the normal ranges in all the patients. Creatinine and uric acid were within the normal ranges, while urea was significantly increased and out of the normal clinical range in both hypothyroid and hyperthyroid patients (39.560 ± 9.912 for hypothyroidism patients and 42.460 ±7.171 for hyperthyroid patients vs. 26.920 ± 5.033 for controls, p <0.0001). Conclusion. Vitamin D3 and kidney function tests must be included in the differential detection of thyroid diseases. Still, further investigations are needed to understand the underlying mechanism by which VD affects thyroid hormone regulation.
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