Oxidative stress is a condition that can damage human cells and tissues and has been linked to a number of illnesses, including cancer, cardiovascular disease, autoimmune disorders, and neurological diseases. Oxidative stress conditions can be brought on by pollution, radiation exposure, and an unhealthy lifestyle. Antioxidants are substances that can be used to both prevent and treat oxidative stress. This study aimed to identify and quantify (+)-catechin levels and antioxidant activity of the stem bark of Sterculia quadrifida R. Br extracted by the infusion method, a method similar to traditional medicine processing generally in the community. Determination of (+)-catechin and antioxidant activity of S. quadrifida were evaluated by HPLC and DPPH assay, respectively. Quantification of (+) catechin content by HPLC system with wavelength 280 nm and antioxidant activity by spectrophotometry method with wavelength 517 nm. The results show that the mean value of (+)-catechin level was 7.786% and the IC50 value of the antioxidant activity was 51.5 ug/mL having a moderate antioxidant activity category. S. quadrifida stem bark infusion can be utilized as a medication candidate for the prevention or treatment of a variety of disorders caused by oxidative stress.
Peran kader sangat penting untuk membantu sosialisasi kegiatan untuk meningkatkan status kesehatan masyarakat, pemerintah kabupaten Sidoarjo berkomitmen meningkatkan status gizi dan ASI eksklusif dengan menetapkan perda nomor 1 tahun 2016, diharapkan seluruh masyarakat mendukung perda tersebut. Di desa Sambibulu juga mendukung tercapainya Asi eksklusif, Kader Desa Durung Bedug Candi Sidoarjo aktif dalam kegiatan dimasyarakat untuk mendukung pembentukan UKBM (upaya kesehatan berbasis masyarakat) selain posyandu terbentuk juga kelompok pundukung ASI (KP ASI) untuk membantu tercapainya ASI eksklusif. Berdasarkan survey yang telah dilakukan oleh tim pengusul pada kader didapatkan hasil bahwa cakupan ASI eksklusif masih rendah yakni 56% dari target 80% dan salah satu penyebabnya yakni karena produksi ASI kurang. Kegitaan KP ASI yang sudah berjalan namun belum terdapat upaya untuk membantu meningkatkan produksi ASI. Kader belum pernah mendapatkan pengetahuan tentang upaya untuk meningkatkan produksi ASI. Berdasarkan permasalahan tersebut tim pengusul menawarkan solusi untuk membantu mengatasi kurangnya pengetahuan dan keterampilan kader dalam meningkatkan produksi ASI. Salah satu upaya yang ditawarkan oleh tim pengusul adalah memberikan sebuah pelatihan dan pendampingan praktek pijat punggung pada kader untuk membantu meningkatkan produksi ASI. Kader Desa Durung Bedug Candi Sidoarjo termasuk kader yang mempunyai loyalitas tinggi dan aktif, sehingga tim pengusul lebih mudah untuk memberikan pelatihan dan pendampingan tentang praktek pijat punggung untuk meningkatkan produksi ASI, yang nantinya diinformasikan kepada masyarakat sebagai upaya untuk meningkatkan produksi ASI dan masyarakat dapat melakukan pijat punggung secara mandiri.
Rifampicin is an anti-tuberculosis drug which has an efficient antimicrobial effect and the basis of a short-term treatment regimen for tuberculosis (TB) patients. Rifampicin plays an important role against the growth and slow metabolism of Bacilli M. tuberculosis. Resistance to rifampicin causes the duration of tuberculosis treatment to be longer. Interleukin-18 (IL-18) is a pro-inflammatory cytokine which plays a role in controlling the growth of M. tuberculosis through its ability to induce IFN-γ, while Interleukin-10 (IL-10) is an anti-inflammatory cytokine which plays a role in limiting tissue damage due to the inflammatory process and maintain tissue homeostasis. IL-18 and IL-10 has an important role in explaining the different degrees of inflammation in rifampicin resistant (RR) and rifampicin sensitive (RS) pulmonary tuberculosis patients. The purpose of this study is to determine different levels of IL-18 and IL-10 in new TB patients with RR and RS. This study was a retrospective cohort study with a cross-sectional design carried out from August-November 2018 in the TB-DOTS/MDR clinic at Dr. Soetomo Hospital, Surabaya. 50 research subjects were examined and grouped into two groups, namely pulmonary TB with RR (n = 25) and pulmonary TB with RS (n = 25) based on GeneXpert examination and anti-tuberculosis drug therapy ≤ 1 month. IL-18 and IL-10 were measured using the ELISA Method. Differences in IL-18 and IL-10 levels between groups were analyzed using the Mann-Whitney test. The mean level of IL-18 (pg/ml) in RR and RS pulmonary TB patients were 1273.53±749.86 and 787.96 ±589.28 respectively. The mean level of IL-10 (pg/ml) in RR and RS pulmonary TB patients were 125.25±118.32 and 128.81±135.77 repectively. The mean level of IL-18 in RR and RS pulmonary TB patients were found to have a significant difference, while the mean level of IL-10 did not have a significant difference. Keywords: Interleukin-18, Interleukin-10, Tuberculosis, Rifampicin Resistant, Rifampicin Sensitive
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