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Background:Distribution of Hepatitis C Virus (HCV) genotypes may be changed over time. Epidemiological Studies on distribution patterns of HCV genotypes in Pakistani population might assist for better treatment options and preventive strategies.Objectives:This study was conducted to determine distribution patterns of HCV genotypes in different geographical regions of Pakistan.Patients and Methods:In this cross-sectional study, 1818 randomly selected patients from different geographical regions of Pakistan, diagnosed with HCV infection by the third generation Enzyme Linked Immunosorbent Assay (ELISA), were included between April 2011 and December 2013. HCV RNA was detected in serum samples of patients by Reverse Transcription Polymerase Chain Reaction (RT- PCR) of the core region. Qualitative PCR was performed to determine viral load. HCV genotyping was performed by RT-nested PCR using type-specific primers of the core region. Frequency of different genotypes among patients was assessed according to gender, age and geographical region at the time of sampling.Results:Of 1818 HCV RNA positive samples, HCV genotypes PCR fragments were detected in 1552 (85.5%) samples. HCV genotype 3a was the predominant genotype (39.4%) followed by genotype 2a (24.93%). HCV genotype 3 was the predominant genotype in Punjab and Sindh regions, while genotype 2 was the most predominant genotype in Khyber Pakhtunkhwa region and the second predominant genotype after genotype 3 in Sindh region. The incidence of genotype 2a is increasing in our country with decrease in the incidence of genotype 3a. A higher incidence of HCV various genotypes were observed among male patients and those younger than 45 years.Conclusions:This study may facilitate treatment options and preventive strategies in Pakistan.

New multi‐standard wide band filters with compact sizes are designed for wireless communication devices. The proposed structures realize dual‐wideband and quad‐wideband characteristics by using a new skew‐symmetrical coupled pair of asymmetric stepped impedance resonators, combined with other structures. The first and second dual‐wideband filters realize fractional bandwidths (FBW) of 43.2%/31.9% at the central frequencies (CF) of 1.875/1.63 GHz, and second bandwidths of 580 MHz/1.75 GHz at CF of 5.52/4.46 GHz, respectively. The proposed quad‐band filter realizes its first/second/third/fourth pass bands at CF 2.13/5.25/7.685/9.31 GHz with FBW of 46.0%/11.4%/4.6% and 5.4%, respectively. The wide pass bands are attributed to the mutual coupling of the modified ASIR resonators and their bandwidths are controllable by tuning relative parameters while the wide stop band performance is optimized by the novel interdigital cross coupled line structure and parallel uncoupled microstrip line structure. Moreover, the quad band is generated by introducing the novel defected rectangle structure. These multi‐standard filters are simulated, fabricated and measured, and measured results agree well with both simulated results and theory predictions. The good in‐band and out‐of‐band performances, the miniaturized sizes and simple structures of the proposed filters make them very promising for applications in future multi‐standard wireless communication.

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In this study, we propose a design of a multi-band slot antenna array applicable for fourth-generation (4G) and fifth-generation (5G) smartphones. The design is composed of double-element square-ring slot radiators fed by microstrip-line structures for easy integration with radio frequency (RF)/microwave circuitry. The slot radiators are located on the corners of the smartphone printed circuit board (PCB) with an overall dimension of 75 × 150 mm2. The proposed multiple-input multiple-output (MIMO) antenna is designed to meet the requirements of 4G and 5G mobile terminals with essential bandwidth for higher data rate applications. For −10 dB impedance bandwidth, each single-element of the proposed MIMO design can cover the frequency ranges of 2.5–2.7 GHz (long-term evolution (LTE) 2600), 3.45–3.8 GHz (LTE bands 42/43), and 5.00–5.45 GHz (LTE band 46). However, for −6 dB impedance bandwidth, the radiation elements cover the frequency ranges of 2.45–2.82 GHz, 3.35–4.00 GHz, and 4.93–5.73 GHz. By employing the microstrip feed lines at the four different sides of smartphone PCB, the isolation of the radiators has been enhanced and shows better than 17 dB isolation levels over all operational bands. The MIMO antenna is implemented on an FR-4 dielectric and provides good properties including S-parameters, efficiency, and radiation pattern coverage. The performance of the antenna is validated by measurements of the prototype. The simulation results for user-hand/user-head impacts and specific absorption rate (SAR) levels of the antenna are discussed, and good results are achieved. In addition, the antenna elements have the potential to be used as 8-element/dual-polarized resonators.

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This paper presents a compact planar tunable filter covering the 2.5 to 3.8 GHz spectrum for 4G and 5G wireless communications using a new hybrid technique open-circuited stubs. The coupling between the resonators is adjusted to tune the centre frequency with Butterworth characteristics. The proposed bandpass filter (BPF) is designed on a Rogers RO3010 substrate with a relative dielectric constant of 10.2 and a compact size of 13×8×0.81 mm 3 . The coupling coefficients between the adjacent resonators, external quality factors, varactor diodes and biasing circuit are designed to resonate the tunable filter at 3.5 GHz. The bandwidth is adjustable between 90 and 110 MHz with return losses between 15 to 25 dB and insertion loss around 0.8 dB. Computer simulation technology (CST) software is used to simulate and optimize the designed tunable filter, with hybrid co-simulation between CST MWS and CST DS is used to implement the structure, taking into account the SPICE model for the varactor diodes and the effect of the biasing circuit.