Ufasomes are unsaturated fatty acid vesicles. They are the suspensions of fatty acids and their ionized species (soap) which are arranged as closed lipid bilayer. The molecular arrangement in ufasome is that the hydrocarbon tails are oriented towards inferior of the membrane and carbonyl groups are in contact with water. The stability of formulation depends on the selection of fatty acid, pH range, amount of lipoxygenase etc. Film hydration method is used for the preparation of vesicle by using oleic acid as fatty acid principle components. The present article describes about the advantages, disadvantages, method of preparation, in vitro evaluation and resent innovations of ufasomes. The present investigation aims at exploring the potential of fatty acid vesicle for the topical delivery of drugs. Earlier ufasomes where considered as the pre-biotic models for cellular compartments. Now, ufasomes are also found as carriers for horizontal transfer of engineered gene from plants to soil microbes or environment.
The delivery of effective level of therapeutically active compound influences the effectiveness any herbal medication. When administered orally or topically, severe limitations occur in the bioavailability of the same. Compared to the conventional phyto molecules or botanical extracts, planterosomes, which are newly, introduced herbal formulations, show much better bioavailability and actions produced as a result of better absorption profile. Nowadays, natural medicines are used to treat the malnutrition and other nutritional disorders as well as diseases which are prevailing in the recent times. Poor absorption and bioavailability can be observed in several plant extracts as well as phytoconstituents, due to their poor lipid solubility or improper size or sometimes both in combination, resulting in less or no in-vivo actions though they might demonstrate excellent bioavailability in-vitro. This in turn creates a need to work on the development of a new concept in herbal delivery system i.e., "planterosomes" which, due to the presence of phosphatidylcholine, can be absorbed and utilized better and hence produce results which are better in every aspect as compared to those of other conventional herbal extracts. The planterosomal preparations are especially advantageous in the treatment of acute as well as chronic diseases of the liver which may be of toxic or of infective origin or degenerative nature due to their substantially improved pharmacological and pharmacokinetic parameters. They can also be effectively used in the formulation of cosmetic and pharmaceutical compositions as well as in preparations which produce anti-inflammatory activity.
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