Ufasome: A Potential Phospholipid Carrier as a Novel Pharmaceutical Formulation

Nair, Athira J; Aswathi, K; George, Ashitha; Athira, P P; Nair, Sreeja C.

doi:10.7897/2230-8407.050453

Cited by 5 publications

(2 citation statements)

References 10 publications

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“…The MDM program and provision of dry ration packs help bridge this gap to an extent. In an attempt to bring about sustainable improvement in nutritional practices, our unit has focused on locally produced supplements such as the low‐cost enteral formula (LCEF) and the locally manufactured RUTF as well as enriched flours and made‐to‐order high protein snacks; both LCEF and RUTF have been formally evaluated and found effective in weight gain 25,29 …”

Section: Discussionmentioning

confidence: 99%

Impact of a pediatric oncology nutrition program: Lessons learnt over a decade

Prasad

Moulik

Jatia

et al. 2022

Pediatric Blood & Cancer

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Background:The management of malnutrition in children with cancer remains a challenge in low-middle-income countries (LMICs). We describe our pediatric oncology nutrition program and its impact over the past decade. Methods: We evaluated the impact of our nutrition program in accordance with the International Society of Paediatric Oncology-Paediatric Oncology in Developing Countries (SIOP PODC) Nutritional Program Evaluation in the areas of service delivery (number served, increments in delivery, number of trained care providers), patients at-risk (proportion identified with malnutrition at diagnosis/follow-up), and efficiency of nutritional interventions (proportion assessed, proportion achieved healthy weight, clinicians trained). We analyzed available data for trends between 2009 and 2020, and comparisons were made using the Fisher t test. This study was approved by our institutional ethics committee. Results: From 2010 to 2020, 17 749 children treated at our center were beneficiaries of the nutritional program, including assessment and intervention. During this period, trained pediatric nutritionists increased from 2 to 8; SIOP PODC level from 2 to 3-4, and nutrition budget increased 15-fold. At diagnosis (n = 5618) and six-month followup (n = 2674), 59.6% and 51.2% children were undernourished, 34.8% and 43% well nourished, and 4.7% and 5.7% overnourished. From 2016 onward, fewer children were undernourished at follow-up-69.5% (2016), 60% (2018), 54% (2019), and 55% (2020, P < 0.001). The program helped train over 500 clinicians in nutrition. Conclusions: Improved financial support and capacity building have helped build and sustain an effective nutrition program. Priority areas include implementation of best practices, early nutritional intervention, continued education, and locally relevant research.

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Section: Discussionmentioning

confidence: 99%

Impact of a pediatric oncology nutrition program: Lessons learnt over a decade

Prasad

Moulik

Jatia

et al. 2022

Pediatric Blood & Cancer

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“…-12 - (47,76) Fatty acid vesicles lower the phase transition temperature of lipids in biological membranes Bilayer membrane has a fusogenic tendency…”

Section: Recent Advances In Developmentmentioning

confidence: 99%

Recent Advances in Development of Vesicular Carrier for Transdermal Drug Delivery: A Review

Gaur,

Minocha,

Mishra

et al. 2024

Jordan j. pharm. sci.

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Transdermal drug delivery has gained significant attention as a non-invasive and convenient method for administering drugs. However, the stratum corneum, the outermost layer of the skin, poses a significant barrier to drug permeation. To overcome this challenge, vesicular carriers have emerged as promising systems for enhancing drug delivery through the skin. This review highlights recent advances in the development of vesicular carriers for transdermal drug delivery. Liposomes, niosomes, transfersomes, ethosomes, and solid lipid nanoparticles are among the commonly used vesicular carriers. These carriers offer advantages such as improved drug solubility, prolonged drug release, and enhanced drug stability. Additionally, they can encapsulate a wide range of drugs, including hydrophilic and lipophilic compounds. Various strategies have been employed to optimize vesicular carriers for transdermal drug delivery. These include modifying the vesicle composition, size, and surface charge to enhance skin penetration. The incorporation of penetration enhancers, such as surfactants, has also been explored to improve drug permeation across the skin. Furthermore, advancements in nanotechnology have led to the development of novel vesicular carriers, such as nanostructured lipid carriers and elastic liposomes. These carriers offer improved drug loading capacity, sustained release profiles, and enhanced skin penetration. Moreover, the use of vesicular carriers has shown promise in delivering a wide range of therapeutic agents, including small molecules, peptides, proteins, and genetic material. The ability to encapsulate and deliver these diverse drug entities opens new possibilities for transdermal drug delivery in various therapeutic areas.

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