Background: Objective was to study the anxiolytic activity of hydro ethanolic extract of Trema guineensis.Methods: Male swiss albino mice were used. Hydro ethanolic extract of Trema guineensis was administered in the doses of 5, 10 and 20 mg/kg IP hole board (HB), open field (OF), elevated plus maze (EPM) tests were used for determination of anxiolytic activity.Results: The hydro ethanolic extract of Trema guineensis significantly increased the number and duration of head poking in HB test. The extract also significantly increased the time spent and the number of entries in open arm in EPM. In OFT, the extract showed significant increase in number of rearing, assisted rearing and the squares crossed.Conclusions: In the present study, Trema guineensis exhibited anxiolytic activity which might be attributed to its phytoconstituents like alkaloid, steroid and triterpenes. Since Trema guineensis is ubiquitous and abundantly grown, it could be a fairly economical therapeutic agent for management of anxiety disorders.
BACKGROUND: The search for disruption of memory in patients with stroke has been performed, in order to better understand the behavior of these patients and optimize their neuropsychological accompaniment. AIM: To evaluate memory disturbances following stroke in patients; in order to better understand the attitudes of these patients.MATERIALS AND METHOD: Fifty-five (55) patients with stroke participated in a spatial memory test. This test consists in studying the arrangement, the designation and the evocation of images during learning a spatial arrangement. RESULTS: Of the 55 patients, 54.54% of patients passed the test but with later learning. And 45.45% failed at different events, they present real memory problems.CONCLUSION: Our study, confirms that stroke patients face difficulties which often include cognitive impairments, such as memory deficits. Our results indicate that these memory disorders manifest themselves to varying degrees. Indeed, the working memory disorders would be more marked in group II patients than in group I patients or they can be considered transient
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