Serological analysis at day 151 demonstrated similar levels of N were observed in the 2 cohorts, corresponding to levels reported in the MELODY trial. The antidrug-antibody response was low at day 151 [2 of 483 (0.4%) infants in the N group and 9 of 251 infants in the Pa group (3.6%)].At the single RSV season midway point of this study, the safety profile for N appeared comparable to Pa in both preterm infants and those with CHD or CLD. A complete pharmacokinetic and safety analysis of N will become available at the conclusion of this 2-season study.
The synthesis of indium(III) complex of orotic acid (HOA) was described and the composition and the structure of In(III) complex ware determined by means of analytical and spectral analyses. Detailed vibrational analysis of HOA, sodium salt of HOA (NaOA) and In(III)-OA systems based on both the calculated and experimental spectra confirmed the suggested metal-ligand binding mode. The calculated vibrational wavenumbers including IR and Raman scattering activities for the ligand and its In(III) complex were in good agreement with the experimental data. The vibrational analysis performed for the studied species, orotic acid, sodium salt of orotic acid and its In(III) complex, helped to explain the vibrational behaviour of the ligand vibrational modes, sensitive to interaction with In(III). The compounds HOA, NaOA and InOA were investigated for possible antioxidant activity in a model of non-enzyme-induced lipid peroxidation on isolated rat microsomes. On isolated rat microsomes, administered alone, the compounds didn't revealed pro-oxidant effects. In conditions of non-enzyme-induced lipid peroxidation, only the complex InOA showed antioxidant activity. HOA and NaOA didn't reveal antioxidant activity. We suggest that the antioxidant activity of the complex InOA, might be due to the presence of indium(III) in the structure of InOA.
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