Introduction: Obesity is associated with metabolic syndrome. Obesity is a leading preventable cause of death worldwide, with increasing rates in adults and children. Obesity is associated with vitamin D insufficiency and hyperparathyroidism, secondary hypercalcemia. The purpose of this study is to test effect of obesity on Vitamin D and calcium level. Methods: The present study investigated effect of obesity on Vitamin D and calcium level. We studied 150 Subjects with no pre-existing disease and not taking any nutritional suppliments for vitamin D. At a baseline they were asked about their family history of obesity. Subjects are investigated for 25-hydroxyvitamin D [25(OH) D] and serum Total calcium level to study effect of obesity on vitamin D and calcium status. Results: Out of 150 subjects included in the study, 107 had obesity and 43 subjects was non-obese. The Body Mass Index less than 30 is taken as cut off point for defining obesity. The mean value of 25-hydroxyvitamin D was 13ng/ml in the group of obese people and the same was 28ng/ml in the group of non-obese individuals. This change was statistically significant (p<0.05). The mean value of serum Total calcium level was 13mg/dl in the group of obese people and the same was 10mg/dl in the group of non-obese individuals. This change was statistically significant (p<0.05). Conclusions: It is concluded that obese individuals are increased risk of developing Vitamin D Deficiency and secondary hypercalcemia.
Introduction: Myocardial Infarction occurs due to any obstruction in coronary arteries leading to ischemia followed by infarction. It is characterized by systemic inflammation, elevated levels of inflammatory cytokines and atherosclerotic plaques. Plaque formation and Inflammation are significant contributor in the pathophysiology of MI. Antioxidants slow the progression of MI because of their ability to inhibit inflammatory processes. The aim of this study was to test an intervention in patients with MI to assess the effect of dietary lycopene on one of the independent risk factor for MI i. e Serum Homocysteine. Methods: Sixty participants with MI were randomly assigned to two groups: with lycopene intervention and without intervention. The intervention group received 27.212 mg of lycopene per day by drinking 1 serve (approx. 243 grams) of tomato soup for 90 days. Serum lycopene, and Serum Homocysteine were measured. Results: Plasma lycopene levels increased in the intervention group as compared with the non intervention group (0.50 µmol/L to 0.75 µmol/L, P = .002; 0.55 µmol/L to 0.57 µmol/L). Mean serum Homocysteine levels decreased significantly in the intervention group. The mean serum Homocysteine in pre intervention group was 29.77 µmol / L with S.D of 6.97 µmol / L and in post intervention subjects was 11 µmol / L with S.D of 1.96 µmol / L with a p value of 0.0001 which is statistically significant. Conclusions: These findings show that the antioxidant Lycopene in a 90-day intervention of tomato soup significantly decreases S. Hcy (Homocysteine) levels in a sample of patients with MI.
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