Effect of dietary lycopene on inflammatory marker in patients of heart failure

Chauhan, Asutosh P; Shah, Pankil

doi:10.18203/2320-6012.ijrms20151159

Cited by 4 publications

(1 citation statement)

References 33 publications

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“…[ 26 ] Another study by Chauhan AP et al . [ 27 ] found a significant effect of lycopene intervention on the levels of CRP. A pilot study in heart failure patients showed that lycopene intervention decreased CRP level significantly in women but not in men.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular and osteoporosis protection at menopause with lycopene: A placebo-controlled double-blind randomized clinical trial

Meeta¹,

Sharma²,

Unni³

et al. 2022

J Mid-life Health

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Objective: The effect of lycopene (LycoRed) supplementation was evaluated in healthy postmenopausal women by biochemical markers for cardiovascular protection and osteoporosis protection. Study Settings and Design: This was a multi-centric placebo-controlled double-blind randomized clinical trial that screened 198 postmenopausal women at 21 centers across 12 cities in India. Levels of lycopene, lipid profile, high-risk C-reactive protein, and bone turnover markers: amino-terminal propeptide of Type I collagen (P1NP) and C-terminal telopeptide of Type I collagen (β-CTx) were measured at baseline and 6 months postsupplementation with LycoRed or placebo. Interventions: The study was completed with 57 of the 100 women on LycoRed 8 mg (antioxidant potency is equivalent to 24 mg of lycopene) and 43 placebos for 6 months by randomization. Main Outcome Measures: Rise in serum lycopene and effect of serum lycopene on surrogate markers of cardiovascular health and bone health. Results: LycoRed supplementation increases lycopene levels and P1NP and nonsignificant fall in β-CTx levels in healthy postmenopausal women. Conclusions: Lycopene supplementation in Indian menopausal women may confer protection from osteoporosis as shown by the directional change in the surrogate biochemical markers. This study can form a basis for larger studies with different doses to understand the effect of lycopene to prevent and act as adjuvant treatment on clinical endpoints for cardiovascular disease (CVD) and bone health.

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Section: Discussionmentioning

confidence: 99%