Background: Granzymes have distinct substrate specificities and trigger diverse cell death pathways. Results: All human granzymes can target hnRNP K, which is essential for tumor cell viability. Conclusion: Granzyme-mediated cleavage of hnRNP K contributes to the elimination of tumor cells by cytotoxic lymphocytes. Significance: Elucidating granzyme function provides insights into the role of cytotoxic lymphocytes in tumor immunology.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.