Background: Acute leukemia is the causing death between many people. Many previous discussions have showed an correlation between MDR1 polymorphisms and leukemia risk. Objective: This study is used to show a strong significance between the genetic MDR1 polymorphism and leukemia in gene site (C3435T). Methods: A case control study involving 70 leukemia patient and 40 healthy was conducted. Specimens of all patients and controls that carry MDR1.C3435T gene polymorphism were identified by conventional PCR followed by RFLP methods. MDR1 (C3435T) polymorphism, was detected by PCR amplification by using the following primers: forward, primer 5' TTG ATG GCA AAG AAA TAA AGC 3' and reverse primer 5' CTT ACA TTA GGC AGT GAC TCG 3'. Results: Our results were significantly related with development of acute leukemia patients. C3435T allele frequency widely varies between variants people. Conclusion: These polymorphisms are correlated with the advanced risk of acute leukemia.
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