BACKGROUND: This study involved model evaluation of the acute impact of sulfamethoxazole on utilization of peptone mixture and acetate by fast growing microbial cultures under aerobic conditions. These substrates were selected to represent complex and readily biodegradable organic carbon sources, respectively. Acclimated biomass was obtained from two fill/draw reactors sustained at a sludge age of 2 days, one fed with peptone mixture and the other with acetate. Acute inhibition was tested in two parallel sets of batch reactors. Each reactor set was started with acclimated biomass seeding and pulse sulfamethoxazole dosing, including a control reactor without antibiotic addition.

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