Purpose Corporate sustainability is an evolutionary strategic management concept that has now attained much attention both in literature and practice. In the present globalization and digital age, the competitive strengths of technology management (TM) and TQM practices are widely accepted but to what extent these strategies can interact and impact the sustainability performance is unknown. The purpose of this paper is to portray the significant role of TM and TQM in pursuing corporate sustainability performance (CSP) and to investigate their integrated relationship as a common framework. Design/methodology/approach This is a survey-based empirical research that has been carried out by means of development of a survey questionnaire and its distribution to multifaceted business organizations in a developing country. Random sampling technique was used for the data collection from companies registered with the Securities and Exchange Commission of Pakistan (SECP). Response from 209 companies was found useful for analysis in the study. After confirming the questionnaire items for reliability and validity (content, criterion-related and construct validity) correlation, regression, factor analysis, path analysis and mediation analysis were performed through SPSS and AMOS to assess the composition and causal association of factors. Findings Statistical results show that TQM does not only significantly impact CSP but also has an impact on each CSP dimension (economical, social and environmental sustainability performance), whereas TM has an insignificant direct effect on CSP and impacts economical sustainability dimension only. From nine hypotheses, two hypotheses are rejected suggesting that TM does not directly impact social and environmental sustainability. However, when mediation analysis was run by taking TQM as a mediator, the total effect of TM on CSP found significant suggesting that TQM significantly impacts the relationship. Research limitations/implications Paucity of response data can be a limitation for such empirical research. Due to practical limitations and risks in the data presentation of mixed cultural dimensions, the data was collected only from in country organizations. Moreover, respondents in the local country do not keenly participate in such surveys because of a gap between the industry and academia. Practical implications The study attempts to examine the practice and performance levels of CSP, TQM and TM among multi industries, thereby, extending a better understanding of the prevailing situation with regards to these concepts in a developing country. Though the results of the study confine local inferences but the findings can be generalized to other part of the world if further research is carried out with more data. Social implications The study outcomes draw the attention of the country’s executive leadership and the industrial boards toward the implementation of the most top-ranked agenda of sustainability performance in connection to quality and TM practices. One of the major findings reveals that local organizations are primarily more focused toward economical sustainability dimension, however, benefits of economical stability can be improvised to attain environmental and social sustainability performances with desired concentration on technology advancement and TQM culture and practice. Originality/value The study is unique in the prescribed scope which has been carried out in a developing country with focus on strategic concepts, and their interacted relationship, of CSP, TQM and TM in form of proposed research framework. This framework can be used or further investigated for validation, by practitioners and managers working to lead sustainability management in respective areas.
In this paper, we present a new design of hollow, out-of-plane polymeric microneedle with cylindrical side-open holes for transdermal drug delivery (TDD) applications. A detailed literature review of existing designs and analysis work on microneedles is first presented to provide a comprehensive reference for researchers working on design and development of micro-electromechanical system (MEMS)-based microneedles and a source for those outside the field who wish to select the best available microneedle design for a specific drug delivery or biomedical application. Then, the performance of the proposed new design of microneedles is numerically characterized in terms of microneedle strength and flow rate at applied inlet pressures. All the previous designs of hollow microneedles have side-open holes in the lumen section with no integrated reservoir on the same chip. We have proposed a new design with side-open holes in the conical section to ensure drug delivery on skin insertion. Furthermore, the present design has an integrated drug reservoir on the back side of the microneedles. Since MEMS-based, hollow, side-open polymeric microneedles with integrated reservoir is a new research area, there is a notable lack of applicable mathematical models to analytically predict structural and fluid flow under various boundary conditions. That is why, finite element (FE) and computational fluid dynamic (CFD) analysis using ANSYS rather than analytical systems has been used to facilitate design optimization before fabrication. The analysis has involved simulation of structural and CFD analysis on three-dimensional model of microneedle array. The effect of axial and transverse loading on the microneedle during skin insertion is investigated in the stress analysis. The analysis predicts that the resultant stresses due to applied bending and axial loads are in the safe range below the yield strength of the material for the proposed design of the microneedles. In CFD analysis, fluid flow rate and pressure drop in the microneedles at applied inlet pressures are numerically and theoretically investigated. The CFD analysis predicts uniform flow through the microneedle array for each microneedle. Theoretical and numerical results for the flow rate and pressure drop are in close agreement with each other, thereby validating the CFD analysis. For the proposed design of microneedles, feasible fabrication techniques such as micro-hot embossing and ultraviolet excimer laser methods are proposed. The results of the present theoretical study provide valuable benchmark and prediction data to fabricate optimized designs of the polymeric, hollow microneedles, which can be successfully integrated with other microfluidic devices for TDD applications.
In this paper, we present design, fabrication and coupled multifield analysis of hollow out-of-plane silicon microneedles with piezoelectrically actuated microfluidic device for transdermal drug delivery (TDD) system for treatment of cardiovascular or hemodynamic disorders such as hypertension. The mask layout design and fabrication process of silicon microneedles and reservoir involving deep reactive ion etching (DRIE) is first presented. This is followed by actual fabrication of silicon hollow microneedles by a series of combined isotropic and anisotropic etching processes using inductively coupled plasma (ICP) etching technology. Then coupled multifield analysis of a MEMS based piezoelectrically actuated device with integrated silicon microneedles is presented. The coupledfield analysis of hollow silicon microneedle array integrated with piezoelectric micropump has involved structural and fluid field couplings in a sequential structural-fluid analysis on a three-dimensional model of the microfluidic device. The effect of voltage and frequency on silicon membrane deflection and flow rate through the microneedle is investigated in the coupled field analysis using multiple code coupling method. The results of the present study provide valuable benchmark and prediction data to fabricate optimized designs of the silicon hollow microneedle based microfluidic devices for transdermal drug delivery applications.
Purpose – Pakistani aviation industry is at the initial stage of its evolution and is undergoing transformation to a high-tech developed industry. However, the processes and practices in this industry are quite primitive and lack performance-measuring techniques for decision makers. The available literature in the total quality management (TQM) suggests a set of standardized factors for evaluating the performance of any organization. The purpose of this paper is to conduct a research with a view to judge the applicability of these TQM factors for measuring the performance of any aviation manufacturing organization in Pakistan. Design/methodology/approach – This research is focussed on performance evaluation of aviation manufacturing industry of Pakistan through TQM. Eight well-established dimensions of TQM frequently used by renowned researchers were used for an evaluation of the Pakistani Aviation Manufacturing Industry (PAMI), namely top management support, quality information availability, quality information usage, employee training, employee involvement, product/process design, supplier quality and customer orientation. An additional dimension of factual approach to decision making was also used based on the outcome of the pilot survey. Both qualitative and quantitative survey techniques were used for gathering the data for subsequent empirical analysis. Findings – The authors found that the suggested model of measuring organizational performance in PAMI was in general agreement with the TQM model of renowned researchers and can be useful tool for evaluation of quality profile of PAMI organizations. Research limitations/implications – During qualitative interviews with the top management, it was found that some of the PAM organizations did not have the complete data and information about their customers and markets, as well as company's human resource effectiveness, and supplier's performance. Although some of them had started maintaining it recently, but comprehensive longitudinal data were not available, which is quite useful for taking correct decisions. Practical implications – The outcome of this research is expected to contribute in the shape of a TQM measuring tool for decision makers in order to evaluate the performance of any aviation manufacturing organization of Pakistan. This model is, however, required to be empirically tested for its applicability in other regions as well for its generalization. Originality/value – This paper deals with the cross-sectional analysis study of the manufacturing organizations of the Pakistani aviation industry for application of TQM practices. It is an original work undertaken by the authors of this paper where various models have been studied and most commonly used dimensions have been utilized for testing the Pakistani aviation industry.
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