MEMS-based micropumps in drug delivery and biomedical applications

Nisar, Asim; Afzulpurkar, Nitin; Mahaisavariya, Banchong; Tuantranont, Adisorn

doi:10.1016/j.snb.2007.10.064

Cited by 544 publications

(282 citation statements)

References 99 publications

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“…Micro-needle arrays (Ahn et al, 2004;Gattiker et al, 2005;Khanna et al, 2008;Ganesan et al, 2014) and micro-actuators offer an alternative to sample extraction and have been demonstrated in the context of micro total analysis systems (µTAS) and as micro electro mechanical systems (MEMS) (Nisar et al, 2008;.…”

Section: Sample Extractionmentioning

confidence: 99%

Towards autonomous lab-on-a-chip devices for cell phone biosensing

Comina

Suska

Filippini

2016

Biosensors and Bioelectronics

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Modern cell phones are a ubiquitous resource with a residual capacity to accommodate chemical sensing and biosensing capabilities. From the different approaches explored to capitalize on such resource, the use of autonomous disposable lab-on-a-chip (LOC) devices conceived as only accessories to complement cell phones underscores the possibility to entirely retain cell phones ubiquity for distributed biosensing. The technology and principles exploited for autonomous LOC devices are here selected and reviewed focusing on their potential to serve cell phone readout configurations. Together with this requirement, the central aspects of cell phones resources that determine their potential for analytical detection are examined. The conversion of these LOC concepts into universal architectures that are readable on unaccessorized phones is discussed within this context. (C) 2015 Elsevier B.V. All rights reserved.

Funding Agencies|Swedish Research Council (VR) [C0453801]; Carl Tryggers Foundation [CTS14140]

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Section: Sample Extractionmentioning

confidence: 99%

Towards autonomous lab-on-a-chip devices for cell phone biosensing

Comina

Suska

Filippini

2016

Biosensors and Bioelectronics

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Funding Agencies|Swedish Research Council (VR) [C0453801]; Carl Tryggers Foundation [CTS14140]

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“…Furthermore, the advance of micro-and nanolithography technology makes the manufacturing of MEMS devices more reproducible and inexpensive. There are numerous MEMS devices around us such as micro accelerometers [45,46], DMD [45,47,48], MEMS pressure sensors [49,50], micropumps [58][59][60], microvalves [61], optical switches [62,63], inkjet heads, microgrippers [64,65], and microactuators [66][67][68][69][70]. For examples, MEMS accelerometers are employed for crashairbag deployment in automobiles and for motion detection in consumer electronic devices such as game controllers (e.g., Nintendo Wii), iPhone and other smartphones.…”

Section: Electronics and Microsystemsmentioning

confidence: 99%

Review on Micro- and Nanolithography Techniques and their Applications

2012

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Abstract. This article reviews major micro-and nanolithography techniques and their applications from commercial micro devices to emerging applications in nanoscale science and engineering. Micro-and nanolithography has been the key technology in manufacturing of integrated circuits and microchips in the semiconductor industry. Such a technology is also sparking revolutionizing advancements in nanotechnology. The lithography techniques including photolithography, electron beam lithography, focused ion beam lithography, soft lithography, nanoimprint lithography and scanning probe lithography are discussed. Furthermore, their applications are summarized into four major areas: electronics and microsystems, medical and biotech, optics and photonics, and environment and energy harvesting.

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“…It is an implantable DDS like an electroactive polymer container releasing a drug over a long period of time, when it is remotely activated. The pump-based DDS can be placed externally and operated outside the body for drug delivery to transfer the drug in the liquid form from the drug reservoir to the blood vessel or tissue accurately and reliably, compared to conventional routes [19]. A typical drug delivery system based on a micropump is shown in Figure 2.…”

Section: Implantable Drug Delivery Systemsmentioning

confidence: 99%

Towards soft robotic devices for site-specific drug delivery

Alici

2015

Expert Review of Medical Devices

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Considerable research efforts have recently been dedicated to the establishment of various drug delivery systems (DDS) that are mechanical/physical, chemical and biological/molecular DDS. In this paper, we report on the recent advances in site-specific drug delivery (site-specific, controlled, targeted or smart drug delivery are terms used interchangeably in the literature, to mean to transport a drug or a therapeutic agent to a desired location within the body and release it as desired with negligibly small toxicity and side effect compared to classical drug administration means such as peroral, parenteral, transmucosal, topical and inhalation) based on mechanical/physical systems consisting of implantable and robotic drug delivery systems. While we specifically focus on the robotic or autonomous DDS, which can be reprogrammable and provide multiple doses of a drug at a required time and rate, we briefly cover the implanted DDS, which are well-developed relative to the robotic DDS, to highlight the design and performance requirements, and investigate issues associated with the robotic DDS. Critical research issues associated with both DDSs are presented to describe the research challenges ahead of us in order to establish soft robotic devices for clinical and biomedical applications. Towards soft robotic devices for site-specific drug delivery Abstract Considerable research efforts have recently been dedicated to the establishment of various drug delivery systems (DDS) which are mechanical / physical, chemical and biological/molecular DDS. In this paper, we report on recent advances in site-specific drug delivery 1 based on mechanical / physical systems consisting of implantable and robotic drug delivery systems. While we specifically focus on the robotic or autonomous DDS, which can be reprogrammable and provide multiple doses of a drug at a required time and rate, we briefly cover the implanted DDS, which are well-developed relative to the robotic DDS, to highlight the design and performance requirements, and investigate issues associated with the robotic DDS. Critical research issues associated with both DDSs are presented to describe the research challenges ahead of us in order to establish really soft robotic devices for clinical and biomedical applications.

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MEMS-based micropumps in drug delivery and biomedical applications

Cited by 544 publications

References 99 publications

Towards autonomous lab-on-a-chip devices for cell phone biosensing

Towards autonomous lab-on-a-chip devices for cell phone biosensing

Review on Micro- and Nanolithography Techniques and their Applications

Towards soft robotic devices for site-specific drug delivery

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