Ethylene diamine is an organic compound which is a strongly basic amine and is used to conjugate Piperonal, an heterocyclic aldehyde. The ethylene diamine conjugated piperonal was prepared using simple method and the antioxidant assays like DPPH, ABTS, Ferric reducing assay and several other methods were carried out through in vitro assays. The experiments were carried out with unconjugated piperonal and compared with the activity shown by the test sample. The overall result shows a good antioxidant effect when compared with various standard drugs such as ascorbic acid, gallic acid, BHT etc., Hence, the results proved that, conjugated piperonal can be used as antioxidants in scavenging free radicals generated as consequence of various disease condition. Further, the synthesised compound can be explored for various experimental studies to confirm their role in combating various diseases.
Cancer is an emerging disease that pose severe public health problem that has a poor prognosis at early stage encompassing small number of effective therapies leading to high mortality rate at an alarming rate. The cancer cell multiplication and growth can be arrested at an early metastasis stage by inhibiting VEGF involved in angiogenesis. Hence in the present study, insilico approach is followed to screen piperonal and its significant analogues for inhibitory role against VEGF. The molecular properties were analysed using Molinspiration and molecular docking analysis was performed using Glide Schrodinnger. The compounds tenamfetamine and midomafetamine showed better binding strength when compared with Sorafenib.
Keywords: Piperonal, Structural Analogues, Angiogenesis, Metastasis, VEGF, Molecular docking, Autodock.
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