Molecular Docking Analysis of Piperonal and its Analogues as Promising Cancer Therapeutics by Modulating Angiogenesis

Abstract

Cancer is an emerging disease that pose severe public health problem that has a poor prognosis at early stage encompassing small number of effective therapies leading to high mortality rate at an alarming rate. The cancer cell multiplication and growth can be arrested at an early metastasis stage by inhibiting VEGF involved in angiogenesis. Hence in the present study, insilico approach is followed to screen piperonal and its significant analogues for inhibitory role against VEGF. The molecular properties were analysed using Molinspiration and molecular docking analysis was performed using Glide Schrodinnger. The compounds tenamfetamine and midomafetamine showed better binding strength when compared with Sorafenib.
 Keywords: Piperonal, Structural Analogues, Angiogenesis, Metastasis, VEGF, Molecular docking, Autodock.