Background. This study aims at determining the factors associated with anemia among pregnant women of underprivileged ethnic groups attending antenatal care at the provincial level hospital of Province 2. Methods. A hospital-based cross-sectional study was carried out in Janakpur Provincial Hospital of Province 2, Southern Nepal. 287 pregnant women from underprivileged ethnic groups attending antenatal care were selected and interviewed. Face-to-face interviews using a structured questionnaire were undertaken. Anemia status was assessed based on hemoglobin levels determined at the hospital’s laboratory. Bivariate and multiple logistic regression analyses were used to identify the factors associated with anemia. Analyses were performed using IBM SPSS version 23 software. Results. The overall anemia prevalence in the study population was 66.9% (95% CI, 61.1–72.3). The women from most underprivileged ethnic groups (Terai Dalit, Terai Janajati, and Muslims) were twice more likely to be anemic than Madhesi women. Similarly, women having education lower than secondary level were about 3 times more likely to be anemic compared to those with secondary level or higher education. Women who had not completed four antenatal visits were twice more likely to be anemic than those completing all four visits. The odds of anemia were three times higher among pregnant women who had not taken deworming medication compared to their counterparts. Furthermore, women with inadequate dietary diversity were four times more likely to be anemic compared to women having adequate dietary diversity. Conclusions. The prevalence of anemia is a severe public health problem among pregnant women of underprivileged ethnic groups in Province 2. Being Dalit, Janajati, and Muslim, having lower education, less frequent antenatal visits, not receiving deworming medication, and having inadequate dietary diversity are found to be the significant factors. The present study highlights the need of improving the frequency of antenatal visits and coverage of deworming program in ethnic populations. Furthermore, promoting a dietary diversity at the household level would help lower the prevalence of anemia. The study findings also imply that the nutrition interventions to control anemia must target and reach pregnant women from the most-marginalized ethnic groups and those with lower education.

Introduction There is a paucity of data on the impact of COVID-19 pandemic on girls and young women. The study examines the prevalence and correlates of violence and sexual and reproductive health (SRH) service disruption among girls and young women during COVID-19 restrictions and lockdown. Methods An interactive voice response survey was conducted among girls and women aged 18–24 years between 10th March to 24th April 2021. The survey enrolled 1314 participants. Descriptive analysis was used to assess prevalence of violence and SRH service disruption. Two sampled test of proportion was used to asses difference in prevalence of violence before and after the pandemic. Logistic regression was used to examine relationship between the outcome variables and socio demographic predictors. Results The study did not find significant difference in prevalence of violence before and after the pandemic. Education was found to be protective against experience of both physical and sexual violence after the pandemic. Dalit participants were four times more likely to report physical violence after the pandemic than Brahmin/Chhetri participants (OR:3.80; CI:1.41–10.24). Participants from 22-24-year age group were twice as likely to experience sexual violence compared to girls and participants from 18-21year age group (OR:2.25; CI:1.04–4.84). Participants from urban municipalities were 29% less likely to report SRH services disruption than participants from rural municipalities (OR-0.71, 95% CI: 0.55–0.91). Participants with disability were twice as likely to report disruption than participants without disability (OR-2.35, 95% CI: 1.45–3.82). Conclusions To reduce violence against girls and women due to the pandemic, interventions should focus on Dalit women and on preventing education discontinuation among girls and women. SRH service during the pandemic needs to be improved for girls and women with focus on girls and women from rural municipalities and girls and women with disability.

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Objectives Stunting and wasting in early life increase the risk of mortality. While assessed and diagnosed as individual conditions, these two forms of malnutrition often coexist within the same populations and possibly the same individual. The main objective of our analysis was to assess the magnitude of stunting and wasting among Nepali infants in the first 12 months of life and to investigate the association of early life wasting on later stunting. Methods For this analysis, we utilized anthropometric data collected in a longitudinal birth cohort study with 1675 maternal-infant dyads. Birth length and weight were collected within 72 hours of birth in 95% of the infants and 88% were followed through 12 months of age. Length, weight measurements were collected on the infants at 3, 6, 9 and 12 months of age. Measurements were converted to z-scores for weight-for-length (WLZ) and length-for-age (LAZ) using World Health Organization Standards. Outliers were defined as WLZ < -5 or >5 and LAZ < -6 or >6. Wasting was defined as WLZ < -2 and stunting as LAZ < -2. Statistical analyses were conducted in Stata® SE version 14. Results In the study population, 7%, 8%, 14% and 17% were wasted while 13%, 15%, 20% and 28% of infants were stunted at 3, 6, 9 and 12 months, respectively. Bivariate analyses showed significantly positive associations between wasting and stunting at 6, 9 and 12 months of age. After controlling for gender, birth weight, maternal height, maternal education, and household food insecurity, being wasted at any one visit during the first 9 months of life was associated with almost double the odds of being stunted at 9 months (AOR: 1.74 (CI: 1.23–2.48), P = 0.002), as was being wasted at any one visit during the first 12 months of life and stunting at 12 months (AOR: 2.21 (CI: 1.68–2.92), P = 0.000). The number of times wasted in the past year was not associated with higher odds of stunting. Conclusions Both wasting and stunting prevalence increased in Nepali infants in the first 12 months of life. Wasting was a significant predictor of stunting at 9 and 12 months of age. A single episode of wasting was sufficient to increase risk of stunting as observed by the lack of effect of cumulative wasting. Targeting and addressing the wasting observed is critical for long-term well being and development of Nepali infants. Funding Sources AID-OAA-L-1-00005, AID-OAA-L-1-00006, and AID-OAA-G-14-00002.

Background: This study aims to determine the predictors of anemia among pregnant women of underprivileged ethnic groups attending antenatal care at provincial level hospital of Province 2.Methods: A hospital based cross-sectional study was carried out in Janakpur Provincial Hospital of Province 2, Southern Nepal. 287 pregnant women from underprivileged ethnic groups attending antenatal care were selected and interviewed. Face to face interviews using structured questionnaire was undertaken. Anemia status was assessed based on hemoglobin levels determined at the hospital’s laboratory. Bivariate and multiple logistic regression analyses were used to identify the predictors of anemia. Analyses were performed using IBM SPSS version 23 software.Results: The overall anemia prevalence in the study population was 66.9% (95% CI 61.1-72.3). The women from most under-privileged ethnic groups (Terai Dalit, Terai Janajati and Muslims) were twice more likely to be anemic than Madhesi women. Similarly, women having education lower than secondary level were about 3 times more likely to be anemic compared to those with secondary level or higher education. Women who had not completed four antenatal visits were twice more likely to be anemic than those completing all four visits. The odds of anemia were three times higher among pregnant women who had not taken deworming medication compared to their counterparts. Furthermore, women with inadequate dietary diversity were four times more likely to be anemic compared to women having adequate dietary diversity.Conclusions: The prevalence of anemia is a severe public health problem among the pregnant women of under-privileged ethnic groups in Province 2. Being Dalit, Janajati and Muslim, having lower education, less frequent antenatal visits, not receiving deworming medication and having inadequate dietary diversity are found to be the significant predictors. The present study highlights the need of improving the frequency of antenatal visits and coverage of deworming program in ethnic populations. Furthermore, promoting a dietary diversity at the household level would help lower the prevalence of anemia. The study findings also imply that the nutrition interventions to control anemia must target and reach pregnant women from most-marginalized ethnic groups and those with lower education.

Aflatoxin is a secondary fungal metabolite that contaminates foods, mostly staple diets like maize, peanuts, chillies, and even rice. These foods are also a major constituent of weaning food for infants in Asia and Sub-Saharan Africa. The fungal metabolite contaminates food during production, harvest, storage, and processing. The contamination is largely promoted by genotypes of crops, soil conditions, temperate regions, and insect activity. Once ingested into the body, aflatoxins get metabolized into different hydroxylated derivatives such as AFb1, AfM1, AFP1, aflatoxicol, and Aflatoxin B1. AFB1 is the most carcinogenic and potent of the known metabolites and they have been categorized as Group I carcinogenic agents by the International Agency for Research on Cancer. The toxic metabolites of aflatoxins have been found in blood samples, breast milk and also have been shown to traverse the placental route. Through various metabolic pathways aflatoxins are responsible for different types of pathological outcomes like gut enteropathy, anemia, stunting, and other immunological disorders. Moreover, socioeconomic determinants have indirectly shown to be strong predictors of aflatoxins exposure and thus its related pathological outcomes. Since we have a very limited number of researches about aflatoxins, this review altogether puts forward what is known about the toxin and its harmful metabolites. Keywords: Aflatoxins; aflatoxinB1; carcinogens; fungal toxins.