The aim of investigation is to develop the effective delivery system for pain management of rheumatic disorders. The mouth dissolving tablets (MDTs) containing flurbiprofen was developed in order to accomplish enhanced solubility leading to better bioavailability profile. Different ratios, of flurbiprofen and Poly ethylene glycol 6000 i.e. 1:1, 1:2, 1:3, 1:4 and 1:5 were selected for the formulation of mouth dissolving tablets system and prepared by direct compression technique. The prepared batches of mouth dissolving tablets were characterized for thickness, hardness, weight variation, wetting time, disintegration time and drug content. The evaluation data for all batches was satisfactory out of them formulation C3 containing 6% MCC PH-102 (Avicel) showed the best results with a value of 27.3 sec and 37.1 sec for wetting and disintegration, respectively.
Chiral salalen ligands derived from (S)‐proline and derivatives of salicyaldehydes were synthesized, and their in‐situ generated Cu (II) complexes were evaluated in the asymmetric Henry reaction. Salalen ligand of different substituents on the phenyl moiety showed remarkable effect on the enantioselectivity of nitro‐aldol product of 4‐nitrobenzaldehyde and nitromethane. Cu (II) complex generated in situ with (S)‐2‐(tert‐butyl)‐6‐((2‐(((2‐hydroxy‐3‐methylbenzylidene)amino)methyl)pyrrolidin‐1‐yl)methyl) phenol (10 mol%) and Cu (OAc)2.H2O (10 mol%), found to be better catalyst for nitro‐aldol reaction between 4‐nitrobenzaldehyde and nitromethane, gave corresponding product in 85% yield and 88% enantiomeric excess (ee) in isopropanol at 35°C after 40 hours. The catalyst also used for the Henry reaction with different substituted benzaldehydes and corresponding products were obtained in 22% to 99% yields with 66% to 92% ee. Henry reaction of 4‐nitrobenzaldehyde and prochiral nitroethane gave anti‐selective product (dr = 79/21; anti/syn) in a 91% yield with 80% ee.
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