Preparation and Evaluation of Mouth Dissolving Tablets of Flurbiprofen

Abstract

The aim of investigation is to develop the effective delivery system for pain management of rheumatic disorders. The mouth dissolving tablets (MDTs) containing flurbiprofen was developed in order to accomplish enhanced solubility leading to better bioavailability profile. Different ratios, of flurbiprofen and Poly ethylene glycol 6000 i.e. 1:1, 1:2, 1:3, 1:4 and 1:5 were selected for the formulation of mouth dissolving tablets system and prepared by direct compression technique. The prepared batches of mouth dissolving tablets were characterized for thickness, hardness, weight variation, wetting time, disintegration time and drug content. The evaluation data for all batches was satisfactory out of them formulation C3 containing 6% MCC PH-102 (Avicel) showed the best results with a value of 27.3 sec and 37.1 sec for wetting and disintegration, respectively.