The present review is focused on the use of MSCs due to their unique immunomodulatory characteristics. MSCs reach to the site of inflammation and interact with immune cells to bring immunosuppressive and anti-inflammatory effects. Along with these unique therapeutic properties, MSCs may be a useful therapeutic approach for various disorders.
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has caused more than 18 million confirmed cases and 700000 deaths worldwide after the outbreak in November 2019 (COVID-19). It has been considered as most pathogenic infection under this category. Till date none of the therapeutics or prophylaxis measures have been claimed by any researcher which could cure the patient suffering from the SARS-CoV-2 infection. There is an urgent need for any alternative and effective way of disease management for COVID-19. However, convalescent plasma therapy (CPT) has gain attention of researchers with significant improvement of patient survival rate. Interestingly, there are numerous examples where CPT has proven its potential upon post-exposure prophylaxis and/or treatment in various diseases including COVID-19. This review summarizes the essential elements related to CPT, its past clinical evidences and application of CPT for the management of SARS-CoV-2 infection during COVID-19. We used the published literatures from PubMed, EMBASE and Medline databases until 31st May 2020.
Cellulases are one of the important groups of industrial hydrolases which hydrolyze lignocellulosics into glucose, hence find numerous applications in the food, feed and beverage industry, textile, pulp and paper industry and biofuel production. With a view of industrial importance of cellulases, this study aimed to screen the cellulolytic potential of fungus Thermomucor indicae-seudaticae sp. nov. The zone of cellulose hydrolysis producing around the growth of fungus confirmed its cellulase-producing ability. Further, the enzyme production was carried out under liquid fermentation and various culture conditions were optimized. Among the physical conditions, maximum enzyme production was obtained at pH 7.0, incubation temperature of 50°C and incubation period of 7 days. Corn cob as carbon source followed by rice straw enhanced the enzyme production. Yeast extract was found to be the best nitrogen source. The crude enzyme exhibited highest enzyme activity at pH 7.0 and temperature 45oC. Among the various additives tested, some metal ions (Na+, K+, Ca+2 and Mg+2) stimulated the enzyme activity while Hg+2 strongly inhibited the enzyme. Among the detergents, SDS had stimulatory effect while Triton X-100 was found inhibitory for cellulase.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.