The presence of a perforation is known to significantly compromise the outcome of endodontic treatment. One potential use of regenerative endodontic therapy may be the repair of root canal perforations. In addition to nutrients and systemic in-situ interactions, the three main components believed to be essential for tissue regeneration are: stem cells, scaffold, and growth factors. This study investigated the role of each component of the tissue engineering triad in the organization and differentiation of Dental Pulp Stem Cells (DPSCs) in a simulated furcal perforation site using a mouse model. Collagen served as the scaffold and dentin matrix protein 1 (DMP1) was the growth factor. Materials were placed in simulated perforation sites in dentin slices. MTA was the control repair material. At six weeks, the animals were sacrificed and the perforation sites were evaluated by light microscopy and histological staining. Organization of newly derived pulp tissue was seen in the group containing the triad of DPSCs, a collagen scaffold, and DMP1. The other four groups did not demonstrate any apparent tissue organization. Under the conditions of the present study, it may be concluded that the triad of DPSCs, a collagen scaffold, and DMP1 can induce an organized matrix formation similar to that of pulpal tissue, which may lead to hard tissue formation.
This paper outlines the benefits of combining wide-area monitoring and control systems with demand-side management applications for more effective network utilization. Besides a general overview of these two powerful technologies in combination, a technical architecture, and economic benefit in the context of power system operation is encouraged. A case, where a wind park's feed into a neighboring system and wind power generation's non-deterministic behavior caused expensive spot market energy purchase, demonstrates the impact of the proposed wide-area measurement system with ripple control for demand-side management. This example underlines application areas for some typical network configurations with decentralized power generation or dedicated corridors to neighbored systems. It further shows the potential of the proposed load-control scheme with respect to economic, ecological, and reliable power system operation against the background of increasingly decentralized and renewable generation units.Index Terms-Demand-side management (DSM), effective network load-control, postponement of investments, power system control, utilization, wide-area measurement, wind power integration.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.