Premenstrual syndrome (PMS) and primary dysmenorrhea are common complaints among young women. This study evaluated the effects of curcumin supplements on symptoms of pain in young women with PMS and dysmenorrhea. A randomized, triple-blinded, placebo-controlled clinical trial was undertaken. Women who suffered from both PMS and dysmenorrhea were enrolled, and were randomly allocated to the curcumin (n = 62), or placebo (n = 62) groups. Each subject received one capsule (500 mg of curcuminoid, or placebo) daily, from 7 days pre-until 3 days postmenstruation for three successive menstrual cycles. Participants recorded the severity of PMS, or dysmenorrhea using a Premenstrual Syndrome Screening Tool (PSST) and the visual analog scale, respectively. Baseline characteristics of participants did not differ between the curcumin and placebo groups. At the end of the trial, the PSST scores were significantly lower in both the curcumin (32.5 ± 9.8 vs. 21.6 ± 9.8); and placebo groups (31.7 ± 9.4 vs. 23.4 ± 12.8). There was a significant reduction of dysmenorrhea pain in both the curcumin and placebo groups (by 64% and 53.3%, respectively). Hence, curcumin had comparable effects as placebo, regarding the amelioration of symptoms of PMS and dysmenorrhea. Further studies are required with larger samples, using higher doses curcumin for longer durations, and perhaps in combination therapy.
This experiment was conducted to evaluate the effects of dietary turmeric rhizome powder (TP) on performance, blood metabolite, immune system, antioxidant status, and relative weight of organs in pre and post heat stressed broilers. Two hundred and sixty-four (264) day-old male Arian broiler chicks were randomly allotted to three dietary treatments containing 0, 0.4 or 0.8% turmeric powder. Each diet was fed to four replicates of 22 birds each. Heat stress was applied for 5 h (33°C) from 28 to 42 days. Two birds from each replicate were randomly selected and blood samples were taken to collect the serum, plasma and whole blood. These were slaughtered to determine the relative weight of organs pre (28 days PHS) and after heat stress (42 days AHS). TP did not affect feed intake, body weight, feed conversion ratio (FCR), production index, and protein and energy efficiency ratio of broilers. Blood cholesterol and low density lipoprotein (LDL) decreased and blood high density lipoprotein (HDL) increased when fed TP in PHS and AHS birds. TP did not affect serum triglyceride, protein, antibody production against sheep red blood cell (SRBC), IgG, IgM and Newcastle vaccination (ND) in PHS and AHS. TP suppressed the enzyme activity of lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) of heat stressed birds. The enzyme activity of creatine kinase (CK) in AHS and superoxide dismutase (SOD) in PHS were not affected by TP diets. TP diets increased blood activity of glutathione peroxidase (GPx) and SOD and decreased blood thiobarbituric acid reactive substances (TBARS) index. The H:L ratio, relative weight of bursa of fabircus and abdominal fat decreased in birds fed TP diets. TP diets did not alter percentage of bone Ash, and P of heat stress broilers; however, it increased bone Ca of heat stressed broilers. It can be concluded that the supplementation of TP to diets, decreased the activity of dehydrogenase enzyme, stressor index, and improved the antioxidant status without affecting performance and the immune system of heat stressed broilers.
There are several successive and overlapping phases in wound healing as a complex process. By the disruption of each of these phases, chronic non-healing wounds are resultant. Despite the present soothing surgeries, standard wound dressings and topical gels, the wound is often not completely closed. Today, stem cells have attracted a huge deal of attention therapeutically and pharmaceutically considering their unique features. However, they have some restrictions. Moreover, it is hoped to eliminate the limitations of cellular therapies based on their derivatives known as exosomes. Exosomes are extracellular vesicles secreted from cells. They have a diameter of almost 30-150 nm and miRNAs, mRNAs, and proteins that are possibly different from the source cell are included in exosomal contents. Such nanovesicles have a key role in the intercellular communication of pathological and physiological procedures. Exosome-based therapy is a new significant method for wound healing. By exosomes effects, wound management may be improved and a new therapeutic model may be highlighted for cell-free therapies with reduced side effects for the wound repair.
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