The aim of the present study was to develop tizanidine controlled release matrix. Formulations were designed using central composite method with the help of design expert version 7.0 software. Avicel pH 101 in the range of 14-50% was used as a filler, while HPMC K4M and K100M in the range of 25-55%, Ethylcellulose 10 ST and 10FP in the range of 15 -45% and Kollidon SR in the range of 25-60% were used as controlled release agents in designing different formulations. Various physical parameters including powder flow for blends and weight variation, thickness, hardness, friability, disintegration time and in-vitro release were tested for tablets. Assay of tablets were also performed as specified in USP 35 NF 32. Physical parameters of both powder blend and compressed tablets such as compressibility index, angle of repose, weight variation, thickness, hardness, friability, disintegration time and assay were evaluated and found to be satisfactory for formulations K4M2,
Mayer-Rokitansky-Kuster-Hauser Syndrome is a rare condition in which Müllerian system does not develop and ends up with rudimentary upper vagina and the uterus. As compared to normal physiology of the ovaries and puberty, the patients present with primary amenorrhoea a key clinical symptom. However, the exact aetiology of the disease is still unknown. A few reports considered environmental and epigenetic changes, hormonal imbalance, and cellular receptor abnormalities as possible risk factors associated with the disease.
This case was reported at the Department of Family Medicine, The Indus Hospital, Karachi. A 24-year-old woman, married for eight months, presented with primary amenorrhoea and painful intercourse. Upon detailed clinical evaluation and relevant radiological and diagnostic investigation, an assessment, of Mayer-Rokitansky syndrome was made.
Keywords: Primary Amenorrhoea, Mullerian agenesis, Mayer-Rokitansky-Kuster- Hauser Syndrome.
Pakistan as being the part of a low average income country, where life is not easy for common man, the new technology acceptability in health management is a real risk. The case become worst where people totally rely on traditional method of treatment instead of highly advanced one. The use of wireless controlled microchips is an emerging technology in drug delivery system. The microchips devices implanted in patients and controlled by microprocessor wireless communication. Wireless drug delivery system (WDDS) has the potential to improve patient compliance. The aim of present study is to check the possible acceptability of WDDS in chronic ailment patients in Karachi, Pakistan. A questionnaire based survey was conducted among three different categories of patients with chronic illness after giving a brief awareness of WDDS technology. A total of 150 participants took part in the study. A large proportion of participants were believed in new technology for cure of their chronic disease. The study results also showed that about 65 % of chronic ailment patients will rely on western world drug research trials. About 75 % have shown consent to adapt WDDS technology after complete trial data. From the study performed it clearly understood that any effort and future development in WDDS will be highly appreciated and adopted among chronic ailment patients in Karachi, Pakistan.
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