Use of hydrophilic and hydrophobic polymers for the development of controlled release tizanidine matrix tablets

Ali, Tariq; Shoaib, Mohammad; Yousuf, Rabia Ismail; Jabeen, Sobia; Muhammad, Iyad Naeem; Tariq, Asfia

doi:10.1590/s1984-82502014000400016

Cited by 11 publications

(6 citation statements)

References 42 publications

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“…Sifat mengembang polimer hidrofilik seperti polivinil alkohol akan membentuk lapisan gel yang akan mengontrol pelepasan obat. Formulasi matriks yang menggunakan polimer hidrofilik dan lipofilik, pelepasan obat sangat dipengaruhi oleh disolusi obat yang selanjutnya obat yang larut baru dapat keluar dari jaringan pori polimer (23) .…”

Section: K a N D U N G A N L E M B A B M A T R I K S P A T C Hunclassified

Pengaruh Polimer dan Peningkat Penetrasi Terhadap Karakter Penetrasi Matriks Sediaan Patch Transdermal Karvedilol

Ramadhani

Djajadisastra

Iskandarsyah

2017

jifi

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Carvedilol is β-blocker antihypertensive drug with low oral bioavaibility and short half time which causes the frequency of oral drug used more often or the oral dose might be increased. Transdermal patch with the matrix system can deliver drug through skin in controlled within specifi c time period and hopefully it can improve carvedilol bioavaibility and convenience for patients.The aim of research was to fi nd out the effect of polymer and penetration enhancer toward penetration characteristic of carvedilol transdermal patch matrix seen from kinetics release data and penetration data of carvedilol. The polymer ratio of Polyvinyl Alcohol (PVA) : Ethyl cellulose (ES) polymers and Sorbitan Monolaurate (SM) as penetration enhancer concentrations used were F1 (1:1) / 8%, F2 (1: 1) /10%, F3 (2:1) /8%, F4 (2:1)/10%. Formula F1 did not pass in the organoleptictes so next test only carried out for formula F2, F3 and F4. The in vitro release of carvedilol showed formula F2, F3 and F4 lasted for 24 hours and the released kinetics of carvedilol followed the order of 0 and Higuchi. Carvedilol % cumulative from penetration test in vitro showed for F2, F3 and F4 formulas respectively were 15,384%, 16,495% and 18,287%.

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Section: K a N D U N G A N L E M B A B M A T R I K S P A T C Hunclassified

Pengaruh Polimer dan Peningkat Penetrasi Terhadap Karakter Penetrasi Matriks Sediaan Patch Transdermal Karvedilol

Ramadhani

Djajadisastra

Iskandarsyah

2017

jifi

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“…Among the polymer matrices used for the development of oral formulations, the polymeric matrices formed by hydrophilic polymers and their nanocomposites are often used as pharmaceutical excipients due to their low cost and ease of processing. 4,5 Polyvinylpyrrolidone (PVP) is a vinyl polymer that is water-soluble, highly amorphous, inert in the human body, and is normally used as a pharmaceutical excipient, lubricant, and emulsifying agent; It is non-toxic and biocompatible, representing an alternative to the hydrophilic polymer as a matrix. 6,7 Polymer/montmorillonite (MMT) nanocomposites have shown advantages in terms of architecture and morphology formation, such as exfoliation and intercalation.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, considerable research has been conducted to produce nanostructured materials containing inorganic nanofillers dispersed in a polymer matrix. Among the polymer matrices used for the development of oral formulations, the polymeric matrices formed by hydrophilic polymers and their nanocomposites are often used as pharmaceutical excipients due to their low cost and ease of processing 4,5 …”

Section: Introductionmentioning

confidence: 99%

Development of polyvinylpyrrolidone, inorganic nanoparticles, and lithium carbonate nanostructured systems

Farias

Silva

Tavares

et al. 2023

Polymer Engineering & Sci

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Nanocomposites with inorganic nanofillers spread in a polymer matrix have been used for the development of pharmaceutical systems to treat mental illnesses such as bipolar disorder and Alzheimer's disease. In this study, nanostructured particles using a solution intercalation technique combined with a spray‐drying process using polyvinylpyrrolidone (PVP), montmorillonite, titanium dioxide, and lithium carbonate, with the aim of designing a new drug delivery system. XRD and low‐field nuclear magnetic resonance analyses showed that PVP/MMT 1% achieved an intercalated/exfoliated morphology. However, the incorporation of TiO2 nanoparticles into the PVP matrix did not affect its structure, indicating that there was not a strong interaction between the polymer and the TiO2 nanoparticles. Thermal analysis did not reveal any changes in the nanocomposites compared to the pure polymer. Scanning electron microscopy (SEM) analysis revealed a pseudo‐spherical shape, and SEM‐energy‐dispersive x‐ray spectrometry (EDS) confirmed the dispersion of MMT in the PVP matrix. The introduction of lithium carbonate into the PVP/MMT matrix created a new system with higher molecular mobility; the drug introduction increased the mean droplet size, and the zeta potential remained negative. Overall, the results indicate that the applied methodology can produce a new nanostructured particle as a drug delivery system.

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“…These polymers have been extensively used in advanced pharmaceutical dosage form designs for a variety of purposes such as matrix system carriers for drug in oral drug delivery systems (Debotton and Dahan, 2017). These applications in oral dosages are dependent on their hydrophilic and hydrophobic properties (Ali et al, 2014). Polymers such as xanthan gum, sodium alginate, hydroxyl ethyl cellulose (HEC), hydroxyl propyl methyl cellulose (HPMC), hydroxyl propyl cellulose (HPC) and polyethylene oxides are hydrophilic and hence used in enhancing the release rates of drugs (Gupta et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Formulation of sustained release diclofenac sodium tablets using a blend of hydrophobic and hydrophilic polymers

O Eraga,

N Ijeh,

D Nnamani

et al. 2023

Drug Dicov

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The limitations of conventional oral dosage forms, particularly those containing drugs with short biological half-lives has led to the development of sustained release formulations. The objective of this study was to develop a sustained release diclofenac sodium tablets using a hydrophobic (Eudragit RS PO) polymer in combination with hydrophilic polymers (Abelmoschus esculentus and polyethylene glycol) as release rate control agents. Nine (9) batches of diclofenac sodium granules (B1-B9) were prepared with a combination of Eudragit RS PO, Abelmoschus esculentus powder and polyethylene glycol (PEG) at different ratios and compressed into tablets via direct compression. The granules were evaluated for flow properties while the tablets were analyzed for their weight uniformity, dimensions, friability, crushing strength and in-vitro drug release. Drug-excipient interactions study was carried out using Fourier transform infra-red spectroscopy (FTIR). Bulk and tapped densities of the granules ranged 0.41-0.58 and 0.50-0.72 g/cm 3 , respectively, with Carr's indices (11.9 -20.8%), Hausner's ratios (1.14 -1.26) and angles of repose (< 30°). Formulated tablets had uniform weight, friability ≤ 0.50% and crushing strength range of 3.15 -7.89 kp. Tablet showed variable sustained drug release with highest release of over 70% in 7 h. FTIR study showed no interaction between drug and excipients. Sustained release tablets of diclofenac sodium were successfully prepared with Eudragit RS PO and a combination of Abelmoschus esculentus powder and polyethylene glycol (PEG) as release modifiers. Batches B6 and B9 tablets released over 70% of drug within 7 h of dissolution testing.

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Use of hydrophilic and hydrophobic polymers for the development of controlled release tizanidine matrix tablets

Cited by 11 publications

References 42 publications

Pengaruh Polimer dan Peningkat Penetrasi Terhadap Karakter Penetrasi Matriks Sediaan Patch Transdermal Karvedilol

Pengaruh Polimer dan Peningkat Penetrasi Terhadap Karakter Penetrasi Matriks Sediaan Patch Transdermal Karvedilol

Development of polyvinylpyrrolidone, inorganic nanoparticles, and lithium carbonate nanostructured systems

Formulation of sustained release diclofenac sodium tablets using a blend of hydrophobic and hydrophilic polymers

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